Actividad Investigadora
Carlos Ignacio Lordá Díez
Área de Cáncer
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16Currículum vitae
Carlos I. Lorda Diez is lecturer in Anatomy (fixed-term contract) in the Department of Anatomy and Cell Biology of the University of Cantabria. His research activity focusses in the analysis of factors that determine the differentiation of mesenchymal progenitor cells into skeletal connective tissues, including the analysis of their diversification to form cartilage and tendons, or towards programmed cell death processes to sculpt the definitive form of the skeletal elements. The article entitled "The transformation of growth factors ? (TGF?) coordinates the differentiation of cartilage and tendon in the mesenchyme of the developing limb" was the basis of his PhD Thesis (Extraordinary Doctorate Award and Social Council Award for Best PhD Thesis) and it was published in "Journal of Biological Chemistry". This article shows the crucial role TGF? proteins in the differentiation of progenitors towards tendon and fibrous connective tissue. Employing different experimental approaches, his work has showed that skeletal progenitors follow successive stages of differentiation, which are determinants for progenitors to respond to chondrogenic or tenogenic factors. These data have been published in several publications. Two of these articles have been published in the "PLoS One" journal, including an exhaustive study of the sequential gene regulation involved in the differentiation process and the influence of extracellular BMP antagonists on this process. The article "Divergent functions dependent on the stage and ligand of BMP signaling in the differentiation of skeletal progenitors of in vitro embryos", published in the "Journal of Bone and Mineral Research", shows that the response to BMP signaling depend mainly on the state of differentiation in which cells are located and not in the type of BMP protein administered, which is very important for the use of these factors in regenerative medicine. An additional aspect in his research is the study of intermediary signals that participate in the regulation of the morphogenic processes, including studies on the role of miRNAs, transcription factors (Sox9, Btg1, Btg2, Id2, ...) extracellular proteins (DECORIN, REELIN, BIGH3, ...), and also is author of several review articles summarizing the latest technical knowledge on the molecular mechanisms of connective tissue differentiation in the developing limb.
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