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Sirolimus in de novo heart transplant recipients with severe renal impairment.

Fecha de publicación:

Autores de IDIVAL

Autores ajenos al IDIVAL

  • Piñera C
  • Duran RM

Abstract

Two patients with end-stage heart failure and advanced renal dysfunction (under chronic dialysis therapy) underwent heart transplantation. In order to avoid further renal impairment, a calcineurine inhibitor-free immunosuppression regimen based on the sirolimus was used. Although temporary perioperative support with hemofiltration and dialysis was needed, both patients eventually regained a reasonable renal function with no episodes of clinical rejection and normal cardiac function at 13 and 11 months, respectively, after transplantation. Sirolimus-based immunosuppression might be an interesting alternative to calcineurine inhibitors in the management of patients with significant renal impairment.

Datos de la publicación

ISSN/ISSNe:
0934-0874, 1432-2277

Transplant International  Wiley-Blackwell

Tipo:
Article
Páginas:
245-248
PubMed:
16441775

Citas Recibidas en Web of Science: 10

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Keywords

  • heart transplantation; immunosuppression; renal failure and sirolimus

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