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Shift work and colorectal cancer risk in the MCC-Spain case-control study

Fecha de publicación:

Autores de IDIVAL

  • Inés Gómez Acebo

    Autor

  • Trinidad Dierssen Sotos

    Autor

Autores ajenos al IDIVAL

  • Papantoniou, K
  • Castano-Vinyals, G
  • Espinosa, A
  • Turner, MC
  • Alonso-Aguado, MH
  • Martin, V
  • Aragones, N
  • Perez-Gomez, B
  • Pozo, BM
  • Ardanaz, E
  • Altzibar, JM
  • Peiro, R
  • Tardon, A
  • Lorca, JA
  • Chirlaque, MD
  • Garcia-Palomo, A
  • Jimenez-Moleon, JJ
  • Ederra, M
  • Amiano, P
  • Pollan, M
  • Moreno, V
  • Kogevinas, M

Unidades

Abstract

Objectives Shift work that involves circadian disruption has been associated with a higher cancer risk. Most epidemiological studies to date have focused on breast cancer risk and evidence for other common tumors is limited. We evaluated the risk for colorectal cancer (CRC) in relation to shift work history in a population-based case-control study in Spain. Methods This analysis included 1626 incident CRC cases and 3378 randomly selected population controls of both sexes, enrolled in 11 regions of Spain. Sociodemographic and lifestyle information was assessed in face-to-face interviews. Shift work was assessed in detail throughout lifetime occupational history. We estimated the risk of colon and rectal cancer associated with rotating and permanent shift work (ever, cumulative duration, age of first exposure) using unconditional logistic regression analysis adjusting for potential confounders. Results Having ever performed rotating shift work (morning, evening and/or night) was associated with an increased risk for CRC [odds ratio (OR) 1.22, 95% confidence interval (95% CI) 1.04-1.43], as compared to day workers. Having ever worked permanent night shifts (>= 3 nights/month) was not associated with CRC risk (OR 0.79, 95% CI 0.62-1.00). OR increased with increasing lifetime cumulative duration of rotating shift work (P-value for trend 0.005) and were highest among subjects in the top quartiles of exposure (3rd quartile, 20-34 years, OR 1.38, 95% CI 1.06-1.81; 4th quartile, >= 35 years, OR 1.36, 95% CI 1.02-1.79). Conclusions These data suggest that rotating shift work may increase the risk of CRC especially after longterm exposures.

Datos de la publicación

ISSN/ISSNe:
0355-3140, 1795-990X

SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH  Nordic Association of Occupational Safety and Health (NOROSH)

Tipo:
Article
Páginas:
250-259
PubMed:
28251241

Citas Recibidas en Web of Science: 38

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Keywords

  • circadian disruption; colon cancer; lifestyle; night work; prevention; rectal cancer; rotating shift work; shift worker

Proyectos asociados

Variantes genéticas y pathways relacionadas con cánceres de mama y próstata, y su interacción con la exposición a hormonas sexuales endógenas y exógenas: estudio MCC-Spain

Investigador Principal: Javier Llorca Díaz

PI12/00715 . INSTITUTO DE SALUD CARLOS III. . 2013

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