Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics.

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Oliveira J
  • Gallo J
  • Bañobre-López M

Unidades de Investigación

Abstract

Nowadays, a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations. Thus, the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical applications. Herein, a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient, green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug (doxorubicin) into a natural nano-matrix. The theranostic performance of the final magnetic formulation was validated in vitro and in vivo , in melanoma tumors. The systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy, together with MRI reporting capability. The application of an alternating magnetic field was found to play a dual role, (i) acting as an extra layer of control (remote, on-demand) over the chemotherapy release and (ii) inducing a local thermal ablation of tumor cells. This combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes, which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.

Datos de la publicación

ISSN/ISSNe:
2452-199X, 2452-199X

Bioactive Materials  KeAi Communications Co

Tipo:
Article
Páginas:
153-164
Factor de Impacto:
0,865 SCImago
Cuartil:
Q2 SCImago

Citas Recibidas en Web of Science: 7

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Keywords

  • Drug delivery systems, Magnetic hyperthermia, Magnetic resonance imaging, Melanoma, Theranosis

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