Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics.

Autores de IDIVAL

• 

  Nuria Terán Villagra

  Autor

  nuria.teran@scsalud.es

• 

  Íñigo Casafont Parra

  Autor

  inigo.casafont@unican.es

• 

  Mónica López Fanarraga

  Autor

  monica.lopez@unican.es

• 

  Lorena García Hevia

  Autor

  lgarcia@idival.org

Autores ajenos al IDIVAL

• Oliveira J
• Gallo J
• Bañobre-López M

Unidades

• NANOMEDICINA

  

  Investigador Responsable

  Mónica López Fanarraga

  monica.lopez@unican.es

Abstract

Nowadays, a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations. Thus, the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical applications. Herein, a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient, green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug (doxorubicin) into a natural nano-matrix. The theranostic performance of the final magnetic formulation was validated in vitro and in vivo , in melanoma tumors. The systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy, together with MRI reporting capability. The application of an alternating magnetic field was found to play a dual role, (i) acting as an extra layer of control (remote, on-demand) over the chemotherapy release and (ii) inducing a local thermal ablation of tumor cells. This combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes, which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.

© 2021 The Authors.

Keywords

• Drug delivery systems, Magnetic hyperthermia, Magnetic resonance imaging, Melanoma, Theranosis