Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics.
Autores de IDIVAL
Autores ajenos al IDIVAL
- Oliveira J
- Gallo J
- Bañobre-López M
Unidades de Investigación
Nowadays, a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations. Thus, the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical applications. Herein, a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient, green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug (doxorubicin) into a natural nano-matrix. The theranostic performance of the final magnetic formulation was validated in vitro and in vivo , in melanoma tumors. The systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy, together with MRI reporting capability. The application of an alternating magnetic field was found to play a dual role, (i) acting as an extra layer of control (remote, on-demand) over the chemotherapy release and (ii) inducing a local thermal ablation of tumor cells. This combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes, which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.
Datos de la publicación
- 2452-199X, 2452-199X
- Factor de Impacto:
- 0,865 SCImago ℠
- Q2 SCImago ℠
Bioactive Materials KeAi Communications Co
Citas Recibidas en Web of Science: 7
- No hay documentos
- Drug delivery systems, Magnetic hyperthermia, Magnetic resonance imaging, Melanoma, Theranosis
García L, Casafont Í, Oliveira J, Terán N, Fanarraga ML, Gallo J, Bañobre M. Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics. Bioact. Mater. 2022. 8. p. 153-164. IF:16,874. (1).