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Antecedentes familiares de primer grado como factor de riesgo en el cáncer colorrectal

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Rubín-García M
  • Martín V
  • Vitelli-Storelli F
  • Moreno V
  • Aragonés N
  • Ardanaz E
  • Jiménez-Moleón JJ
  • Amiano P
  • Fernández-Tardón G
  • Molina-Barceló A
  • Alguacil J
  • Dolores-Chirlaque M
  • Álvarez-Álvarez L
  • Pérez-Gómez B
  • Olmedo-Requena R
  • Guevara M
  • Fernández-Villa T
  • Pollán M
  • Benavente Y

Unidades

Abstract

Abstract Objective To evaluate the association between first-degree family history and colorectal cancer (CRC). Method We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression. Results First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80–2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29–7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52–6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI:2.65–8.65). Conclusions First-degree relatives of CRC increase the chances of developing this tumor,they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures.

Copyright © 2021 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0213-9111, 1578-1283

Gaceta Sanitaria  ELSEVIER

Tipo:
Article
Páginas:
345-352
PubMed:
34272081
Enlace a otro recurso:
www.sciencedirect.com

Citas Recibidas en Web of Science: 2

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Keywords

  • Cáncer colorrectal; Antecedentes familiares; Factor de riesgo; Casos y controles; MCC-Spain; Colorectal cancer; Family history; Risk factor; Case and control; MCC-Spain

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