Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.

Fecha de publicación: Fecha Ahead of Print:

Autores de IDIVAL

Autores ajenos al IDIVAL

  • Pardiñas AF
  • Smart SE
  • Willcocks IR
  • Holmans PA
  • Dennison CA
  • Lynham AJ
  • Legge SE
  • Baune BT
  • Bigdeli TB
  • Cairns MJ
  • Corvin A
  • Fanous AH
  • Frank J
  • Kelly B
  • McQuillin A
  • Melle I
  • Mortensen PB
  • Mowry BJ
  • Pato CN
  • Periyasamy S
  • Rietschel M
  • Rujescu D
  • Simonsen C
  • St Clair D
  • Tooney P
  • Wu JQ
  • Andreassen OA
  • Kowalec K
  • Sullivan PF
  • Murray RM
  • Owen MJ
  • MacCabe JH
  • O'Donovan MC
  • Walters JTR
  • Ajnakina O
  • Alameda L
  • Barnes TRE
  • Berardi D
  • Bonora E
  • Camporesi S
  • Cleusix M
  • Conus P
  • Crespo-Facorro B
  • D'Andrea G
  • Demjaha A
  • Do KQ
  • Doody GA
  • Eap CB
  • Ferchiou A
  • Di Forti M
  • Guidi L
  • Homman L
  • Jenni R
  • Joyce EM
  • Kassoumeri L
  • Khadimallah I
  • Lastrina O
  • Muratori R
  • Noyan H
  • O'Neill FA
  • Pignon B
  • Restellini R
  • Richard JR
  • Schürhoff F
  • Španiel F
  • Szöke A
  • Tarricone I
  • Tortelli A
  • Üçok A

Unidades de Investigación

Abstract

About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizophrenia (TRS). The causes of treatment resistance and their relationships with causes underlying schizophrenia are largely unknown. Adequately powered genetic studies of TRS are scarce because of the difficulty in collecting data from well-characterized TRS cohorts.

Datos de la publicación

ISSN/ISSNe:
2168-622X, 2168-6238

JAMA PSYCHIATRY  AMER MEDICAL ASSOC

Tipo:
Article
Páginas:
260-269
Factor de Impacto:
0,000 SCImago
Cuartil:
Q1 SCImago

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