Alpha-Klotho protein in systemic lupus erythematosus

Fecha de publicación: 01/01/2023 Fecha Ahead of Print: 11/03/2022

Autores de IDIVAL

Miguel Ángel González-Gay Mantecón

Autor

Autores ajenos al IDIVAL

Martín-González C
Gómez-Bernal F
Quevedo-Abeledo JC
Ferrer-Moure C
Espelosín-Ortega E
Ferraz-Amaro I

Abstract

Objective Alpha-Klotho protein (alpha-Klotho) is an essential component of endocrine fibroblast growth factor receptor complexes that governs multiple metabolic processes including aging-related disorders, diabetes, cancer, arteriosclerosis, and chronic kidney disease. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect almost any organ in the body and in which multiple pathophysiological abnormalities are observed. In the present work, our objective was to study whether the serum levels of alpha-Klotho differ between patients with SLE and controls, and how this protein is related to the clinical and laboratory characteristics of the disease. Methods Cross-sectional study that included 364 women, 195 of them diagnosed with SLE and 169 sex- and age-matched controls. Circulating alpha-Klotho was analysed in SLE patients and controls. A multivariable analysis was performed to assess whether alpha-Klotho differs between patients and controls, and to study its relationship with SLE features. Results No differences were found in alpha-Klotho levels between SLE patients and controls, both in univariable and multivariable analyses. Disease-related data like SLE duration, acute phase reactants, activity, severity and damage indices, and autoantibodies profile were not significantly associated with serum levels of alpha-Klotho. However, the use of prednisone and the presence of musculoskeletal manifestations were significantly related to higher alpha-Klotho serum levels. Conclusion alpha-Klotho protein serum levels do not differ between patients with SLE and controls. Nevertheless, SLE patients taking prednisone or those with musculoskeletal manifestations show significantly higher circulating levels of alpha-Klotho.

Datos de la publicación

ISSN/ISSNe:: 0392-856X, 1593-098X
Tipo:: Article
Páginas:: 41-47
DOI:: 10.55563/clinexprheumatol/salqon
PubMed:: 35349421

Documentos

No hay documentos

Métricas

Filiaciones

Martín-González C:: Division of Internal Medicine, Hospital Universitario de Canarias, Tenerife, and Department of Internal Medicine, University of La Laguna, Tenerife, Spain
Gómez-Bernal F:: Division of Central Laboratory, Hospital Universitario de Canarias, Tenerife, Spain
Quevedo-Abeledo JC:: Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Tenerife, Spain
Ferrer-Moure C:: Division of Central Laboratory, Hospital Universitario de Canarias, Tenerife, Spain
Espelosín-Ortega E:: Division of Central Laboratory, Hospital Universitario de Canarias, Tenerife, Spain
González-Gay MÁ:: Instituto de Investigación. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander

Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain

and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ferraz-Amaro I:: Department of Internal Medicine, University of La Laguna, Tenerife, and Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain.