Magnetically propelled chained nanocomposites for biologically relevant media exploration

Autores de IDIVAL

• 

  Mónica López Fanarraga

  Autor

Autores ajenos al IDIVAL

• Ramos-Docampo MA
• Hurtado P
• Dávila-Ibáñez AB
• Piñeiro R
• Salgueiriño V

Unidades

• NANOMEDICINA

  

  Investigador Responsable

  Mónica López Fanarraga

Abstract

Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical informa-tion in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient. Simpler cases of distilled water, a water/glycerol mixture and a fluid made of cell extracts (imitating the cytosol of cells) of known viscosity are the basis experiments for the study of more complex media inside HeLa cells, murine NIH-3T3 fibroblasts and zebrafish larvae, offering the mechanical information required. The experimental results indicate that the magnetically propelled performance of the chained nanostructures can be precisely controlled in potentially changing scenarios, where drug and heat delivery, magnetic separation, or microfluidic technologies are demanded, using a magnetic field gradient and providing good estimations of the dynamical parameters involved.(c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Keywords

• Magnetic swimmers; Magnetophoretic mobility; Viscosity; Zebrafish yolk sac