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  3. The Natural History of Patients With Pre-Existing and De Novo Inflammatory Bowel Disease After Solid Organ Transplantation: EITOS Study of GETECCU.

The Natural History of Patients With Pre-Existing and De Novo Inflammatory Bowel Disease After Solid Organ Transplantation: EITOS Study of GETECCU.

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Bastón-Rey I
  • Rodríguez-Lago I
  • Luque AM
  • Caballol B
  • Soutullo-Castiñeiras C
  • Bravo A
  • Castaño A
  • Gros B
  • Bernal L
  • Diz-Lois MT
  • Alonso-Galán H
  • Cañete F
  • Pérez-Galindo P
  • González-Muñoza C
  • El Hajra I
  • Martínez-Montiel P
  • Alonso-Abreu I
  • Mesonero F
  • González-Vivo M
  • Peries L
  • Martín-Arranz E
  • Abril C
  • Marín-Jiménez I
  • Baltar R
  • Vicuña M
  • Moreno N
  • Brunet E
  • Rubín de Célix C
  • Fajardo I
  • Cruz N
  • Calvino-Suárez C
  • Rojas-Feria M
  • Fernández-Clotet A
  • Gimeno-Torres M
  • Nieto-Garcia L
  • de la Iglesia D
  • Zabana Y
  • Suárez-Ferrer C
  • Barreiro de Acosta M

Unidades

Abstract

BACKGROUND: Limited data are available on the outcome of inflammatory bowel disease (IBD) in patients with solid organ transplantation (SOT). We describe the natural history of pre-existing IBD and de novo IBD after SOT. METHODS: This was a retrospective, multicenter study that included patients with pre-existing IBD at the time of SOT and patients with de novo IBD after SOT. The primary outcome was IBD progression, defined by escalation of medical treatment, surgical therapy, or hospitalization due to refractory IBD. Risk factors were identified using multivariate Cox proportional hazard analysis. RESULTS: A total of 177 patients (106 pre-existing IBD and 71 de novo IBD) were included. Most patients with pre-existing IBD (92.5%) were in remission before SOT. During follow-up, 32% of patients with pre-existing IBD had disease progression, with a median time between SOT and IBD progression of 2.2 (interquartile range, 1.3-4.6) years. In the de novo cohort, 55% of patients had disease progression with a median time to flare of 1.9 (interquartile range, 0.8-3.9) years after diagnosis. In the pre-existing IBD cohort, active IBD at the time of SOT (hazard ratio, 1.80; 95% confidence interval, 1.14-2.84; P = .012) and the presence of extraintestinal manifestations (hazard ratio, 3.10; 95% confidence interval, 1.47-6.54; P = .003) were predictive factors for IBD progression. CONCLUSIONS: One-third of patients with pre-existing IBD and about half of patients with de novo IBD have disease progression after SOT. Active IBD at the time of SOT and the presence of extraintestinal manifestations were identified as risk factors for IBD progression.

© The Author(s) 2024. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Datos de la publicación

ISSN/ISSNe:
1078-0998, 1536-4844

INFLAMMATORY BOWEL DISEASES  WILEY-BLACKWELL

Tipo:
Article
Páginas:
1-10
PubMed:
38518109

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Keywords

  • flare; inflammatory bowel disease; solid organ transplantation

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