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Sex differences in cognitive reserve among first episode of psychosis patients

Fecha de publicación: Fecha Ahead of Print:

Autores de IDIVAL

  • Rebeca Magdaleno Herrero

    Autor

  • Victor Ortiz-Garcia De La Foz

    Autor

  • Nancy Murillo García

    Autor

  • Javier Vázquez Bourgon

    Autor

  • Maria Esther Setien Suero

    Autor

  • Benedicto Crespo Facorro

    Autor

  • María Rosa Ayesa Arriola

    Autor

Unidades

Abstract

Introduction: Cognitive reserve (CR) has recently been considered a key factor in the onset of a first episode of psychosis (FEP). However, the differences in CR in FEP patients according to sex have not yet been investigated. Material and methods: CR was estimated among 443 FEP patients (246 men and 197 women) and 156 healthy controls (96 men and 60 women) by using the proxies premorbid IQ, years of education and employment status. A neuropsychological battery was administrated to measure neurocognitive specific domains. Analyses of variance were used to make comparisons between groups. Results: FEP women had greater CR than FEP men. This circumstance was not observed in healthy controls. Among the group of patients with low CR, FEP women outperformed FEP men in the cognitive domains verbal memory and processing speed. Meanwhile, among the FEP patients with high CR, men showed better performance in attention than women. Conclusions: Differences in CR observed between FEP men and women could be related to a number of specific factors, such as, age at illness onset, education level, and variability in performance in verbal memory, processing speed, and attention domains. These results provide background information about CR in FEP patients that will be useful in the design of sex specific cognitive remediation interventions. (c) 2021 Sociedad Espan similar to ola de Psiquiatria y Salud Mental (SEPSM). Published by Elsevier Espana, S.L.U. All rights reserved.

Copyright © 2021 Sociedad Española de Psiquiatría y Salud Mental (SEPSM). Published by Elsevier España S.L.U. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
2950-2861, 2950-2853

Spanish Journal of Psychiatry and Mental Health  Elsevier

Tipo:
Article
Páginas:
143-150
PubMed:
38520113
Enlace a otro recurso:
www.sciencedirect.com

Citas Recibidas en Web of Science: 5

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Keywords

  • Cognitive reserve; First episodes of psychosis; Cognitive domains; Sex; Neurocognition

Proyectos asociados

10PAFIP neurocognición: Estudio longitudinal a largo plazo (10 años) del funcionamiento cognitivo en pacientes con psicosis del espectro de esquizofrenia

Investigador Principal: María Rosa Ayesa Arriola

PI14/00918 . INSTITUTO DE SALUD CARLOS III. . 2015

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