SEOM-GEICO clinical guidelines on endometrial cancer (2025).

Fecha de publicación: Fecha Ahead of Print:

Autores de IDIVAL

  • Ana De Juan Ferré

    Autor

Autores ajenos al IDIVAL

  • Ramírez SP
  • Fidalgo AP
  • Ginesta MPB
  • Madrid LF
  • Martínez AG
  • Montosa FG
  • Madariaga A
  • Gómez TM
  • Gil-Martin M

Unidades

Abstract

Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. Although most cases are diagnosed at an early stage, prognosis in case of relapse or metastasis remains poor. Molecular characterization of EC is highly recommended as it allows more accurate risk stratification and may modify treatment recommendations. The updated FIGO 2023 staging of EC highlights the importance of traditional clinicopathological factors, while underlining the need for molecular classification to predict outcomes. In early-stage EC, standard treatment consists of total hysterectomy and bilateral salpingo-oophorectomy. Lymph node evaluation remains controversial, as the benefits of systematic lymphadenectomy are unclear. Adjuvant treatment, consisting of radiotherapy, brachytherapy, and chemotherapy, should be chosen according to risk category. In women with advanced or recurrent EC, the combination of carboplatin and paclitaxel has long been standard treatment. However, therapeutic options have changed recently due to advances in immunotherapy. The aim of this guideline is to summarize the current evidence for the diagnosis, treatment, and follow-up of EC, and to provide evidence-based recommendations for clinical practice.

© 2025. The Author(s).

Datos de la publicación

ISSN/ISSNe:
1699-048X, 1699-3055

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico  SPRINGER INT PUBL AG

Tipo:
Article
Páginas:
4368-4380
PubMed:
40986254

Citas Recibidas en Web of Science: 4

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Keywords

  • Diagnosis; Endometrial cancer; Follow-up; Guideline; Treatment

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