Alain Antonio Ocampo Sosa

Área de Patología de Sistemas

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Currículum vitae

Stages in my professional career: · 1995-1998: Researcher. Institute of Tropical Medicine "Pedro Kouri", Havana, Cuba. · 1998: Researcher. Nuclear Laser Medicine, s.r.l. Milano, Italy · 1999-2004: Predoctoral researcher. University of cantabria. · 2005-2007: Postdoctoral researcher. University of Bristol, UK · 2007-2009: Postdoctoral researcher Marie Curie (TOK), NUIG, Ireland. · 2010-2012. Postdoctoral researcher. Training and Research Institute Marquis of Valdecilla. · 2013 to the present. Miguel Servet researcher. Marqués Research Institute of Valdecilla (IDIVAL). In February 1999, after having been working as a researcher in the company italiana Nuclear Laser Medicine s.r.l in Milan, and previously at the Institute of Tropical Medicine "Pedro Kurí", in Havana, Cuba, I begin my doctoral thesis at the University of Cantabria. The reason why I chose this center to train as a researcher was the subject of work, that attracted me powerfully: the molecular typing of the Brucella genus and the mechanism Molecular transposition of a specific insertion sequence of this genus, IS711. At that time there was a need to improve identification procedures and typing of the Brucella genus, since conventional phenotypic methods were very cumbersome. During my PhD studies we were able to develop a rapid method of identification by means of a multipex (AMOS-ERY) that allowed to detect all the species of Brucella and differentiate biovars 3, 5, 6 and 9, from the rest, previously indistinguishable, likewise we could distinguish a new biovar 3b and determine the biological functionality of IS711 in strains of B. ovis and other species isolated from marine mammals. During my first stay postdoctoral at the University of Bristol, UK, I continued to develop identification methods and bacterial typing, but this time in Rhodococcus equi, a pathogen that affects mainly foals, and I participated in the sequencing of the genome of a pathogenic strain of said microorganism and of one of the virulence plasmids of R. equi, pVAPB1593. In my second postdoctoral stay I got a Marie Curie (TOK) scholarship, which I developed in the National University of Ireland in Galway, Ireland, primarily aimed at the study of the mechanisms of resistance to biocides and disinfectants in Pseudomonas aeruginosa and Salmonella enterica. Since 2010 I have been working on the study of mechanisms of resistance to antibiotics in gram negative bacteria of clinical interest such as P. aeruginosa, Burkholderia spp. Klebsiella pneumoniae and Acinetobacter baumannii, among others. Since 2013 I lead my own lines of research funded by the Fondo de Health Research (FIS). The objectives that focus my current research are the study of the mechanisms of resistance to carbapenems in P. aeruginosa, fundamentally mediated by the OprD porina, as well as its regulation and in the study of the systems of type VI secretion (T6SS) in P. aeruginosa and Burkholderia cepacia complex, focusing on the search for new effectors and their interaction with other bacteria and eukaryotic cells, the formation of biofilms and the relationship of these with antibiotic resistance


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