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  3. Leflunomide derivative FK778 inhibits production of antibodies in an experimental model of alloreactive T-B cell interaction.

Leflunomide derivative FK778 inhibits production of antibodies in an experimental model of alloreactive T-B cell interaction.

Fecha de publicación:

Autores de IDIVAL

Autores ajenos al IDIVAL

  • Ramos-Barrón MA
  • Gómez-Alamillo C
  • Cosme LS
  • Gimenez T
  • Merino R
  • Arias M

Abstract

The contribution of humoral immune response in allograft and xenograft rejection has been clearly demonstrated in recent years. For this reason, inhibition of alloantibody production has become essential in managing transplanted patients. Here, we assessed the effects of the leflunomide derivative FK778 (FK778) in the control of antibody production resulting from semiallogeneic cognate T-B-cell interactions.

Datos de la publicación

ISSN/ISSNe:
1304-0855, 2146-8427

EXPERIMENTAL AND CLINICAL TRANSPLANTATION  BASKENT UNIV

Tipo:
Article
Páginas:
218-224
DOI:

Citas Recibidas en Web of Science: 2

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Keywords

  • Allograft rejection; Treatment; Transplant

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