R-COMP versus R-CHOP as first-line therapy for diffuse large B-cell lymphoma in patients =60 years: Results of a randomized phase 2 study from the Spanish GELTAMO group

Autores de IDIVAL

• María Ana Batlle López

  Autor

  mana.batlle@scsalud.es

Autores ajenos al IDIVAL

• Sancho JM
• Fernández-Alvarez R
• Gual-Capllonch F
• González-García E
• Grande C
• Gutiérrez N
• Peñarrubia MJ
• González-Barca E
• Guinea JM
• Gimeno E
• Peñalver FJ
• Fuertes M
• Bastos M
• Hernández-Rivas JÁ
• Moraleda JM
• García O
• Sorigué M
• Martin A

Abstract

The use of non-pegylated liposomal doxorubicin (Myocet(R)) in diffuse large B-cell lymphoma (DLBCL) has been investigated in retrospective and single-arm prospective studies. This was a prospective phase 2 trial of DLBCL patients >= 60 years old with left ventricular ejection fraction (LVEF) >= 55% randomized to standard R-CHOP or investigational R-COMP (with Myocet(R) instead of conventional doxorubicin). The primary end point was to evaluate the differences in subclinical cardiotoxicity, defined as decrease in LVEF to <55% at the end of treatment. Secondary objectives were efficacy, safety, and variations of troponin and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and LVEF along follow-up. Ninety patients were included, 45 in each group. No differences were observed in the percentage of patients with LVEF <55% at end of treatment (11% in R-CHOP arm vs. 7% in R-COMP arm, p = 0.697) or at 4 months (10% vs. 6%, respectively, p = 0.667) and 12 months (8% vs. 7%, respectively, p = 1). However, a higher percentage of R-CHOP compared with R-COMP patients showed increased troponin levels in cycle 6 (100% vs. 63%, p = 0.001) and at 1 month after treatment (88% vs. 56%, respectively, p = 0.015). Cardiovascular adverse events were seen in five R-CHOP patients (nine episodes, four grade >= 3) and in four R-COMP patients (five episodes, all grade 1-2). No significant differences in efficacy were observed. In conclusion, R-COMP is a feasible immunochemotherapy schedule for DLBCL patients >= 60 years, with similar efficacy to R-CHOP. However, the use of non-pegylated doxorubicin instead of conventional doxorubicin was not associated with less early cardiotoxicity, although some reduced cardiac safety signals were observed.

© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Keywords

• N-terminal pro-B-type natriuretic peptide; cardiotoxicity; diffuse large B-cell lymphoma; liposomal doxorubicin; troponin