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Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Ferraz-Amaro I
  • Vicente EF
  • Quevedo-Abeledo JC
  • Rodríguez-Lozano C
  • Ortega-Castro R
  • Ladehesa-Pineda ML
  • Fernández-Carballido C
  • Martínez-Vidal MP
  • Castro-Corredor D
  • Anino-Fernández J
  • García Vivar ML
  • Galíndez-Agirregoikoa E
  • Peiteado D
  • Plasencia-Rodríguez C
  • Montes Perez E
  • Fernández Díaz C
  • Castañeda S

Unidades

Abstract

Background: Axial spondyloarthritis (axSpA) patients are known to have a higher prevalence of several comorbidities, including, among others, an increased risk of atherosclerosis, hypertension, dyslipidemia, and diabetes. The purpose of the present study was to determine whether the sum of traditional cardiovascular (CV) risk factors is related to disease characteristics, such as disease activity, in patients with axSpA. Methods: A cross-sectional study that encompassed 804 patients with axSpA was conducted. Patients were assessed for the presence of five traditional CV risk factors (diabetes mellitus, dyslipidemia, hypertension, obesity, and smoking status), and disease activity measurements. A multivariable regression analysis was performed to evaluate whether the number of classic CV risk factors was independently associated with specific features of the disease, to include disease activity. Results: A multivariable analysis showed that Ankylosing Spondylitis Disease Activity Score-C reactive protein (ASDAS-CRP) activity score was significantly higher in patients with 1 [beta coefficient 0.3 (95% confidence interval (CI) 0.1-0.5), p = 0.001] and > 2 [beta coefficient 0.5 (95% CI 0.3-0.7), p = 0.000] CV risk factors compared with those without CV risk factors. Similarly, patients with 1 [OR 2.00 (95%CI 0.99-4.02), p = 0.053] and > 2 [OR 3.39 (95%CI 1.82-6.31), p = 0.000] CV risk factors had a higher odds ratio for the presence of high disease activity compared with the zero CV category. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) activity score was significantly associated with the number of CV risk factors, being higher in patients with more CV risk factors. These relationships showed a CV risk factor-dependent effect being beta coefficients and ORs higher for the effect of > 2 over 1 CV risk factor. Conclusion: Among patients with axSpA, as the number of traditional CV risk factors increased, disease activity similarly increases in an independent manner.

© The Author(s), 2021.

Datos de la publicación

ISSN/ISSNe:
1759-720X, 1759-7218

Therapeutic advances in musculoskeletal disease  SAGE Publications Inc.

Tipo:
Article
Páginas:
-
PubMed:
34377161

Citas Recibidas en Web of Science: 11

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Keywords

  • axial spondyloarthritis; cardiovascular risk factors; disease activity

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