Actividad Investigadora
Post-transplant diabetes mellitus and renal cell cancer after renal transplantation
Autores de IDIVAL
Autores ajenos al IDIVAL
- Porrini E
- Pérez NM
- Díaz JM
- Lauzurrica R
- Rodríguez JO
- Torres IS
- Moreso F
- Garrit JMC
- Ruiz RB
- Vilaró MI
- Lima MXM
- Ramchand SK
- Gainza de Los Rios F
- Alvarez CR
- Del Carmen de Gracia Guindo M
- Macías M
- Vela DB
- Osuna A
- Bayés-Genís B
- Sanchez CA
- Del Carmen Ruiz M
- Rodríguez AER
- Rinne FG
- Sosa AJ
- Mallén PD
- Rinne AG
- Miranda DM
- Torres A
Unidades
Abstract
Background Diabetes is a risk factor for cancer in the general population. However, few data are available on the association between post-transplant diabetes mellitus (PTDM) and cancer after transplantation. Methods We analyzed this issue in a Spanish cohort of patients without diabetes before transplantation. PTDM was diagnosed with consensus criteria at 12 months after transplantation and 12 months before the diagnosis of cancer. The association between PTDM and cancer (overall and specific types) was evaluated with regression analysis. Results During a follow-up of 12 years (interquartile range 8-14), 85 cases of 603 developed cancer (829/100 000/year) and 164 (27%) PTDM. The most frequent cancers were renal cell cancer (RCC) n = 15, 146/cases/100 000/year), lung (n = 12, 117/cases/100 000/year), colon (n = 9, 88/cases/100 000/year) and prostate (n = 9, 88/cases/100 000/year). In logistic regression, PTDM was not associated with cancer. Eight of the 164 patients with PTDM (4.9%) vs 7 of the 439 without PTDM developed RCC (1.6%) (P = .027). In multivariate analysis, PTDM was independently associated with RCC [odds ratio (OR) 2.92, confidence interval (CI) 1.03-8.27], adjusting for smoking (OR 4.020, 95% CI 1.34-12.02) and other covariates. PTDM was not associated with other types of cancer. Conclusions Patients with PTDM must be considered a population at risk for RCC and accordingly, the subject of active surveillance.
© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.
Datos de la publicación
- ISSN/ISSNe:
- 0931-0509, 1460-2385
- Tipo:
- Article
- Páginas:
- 1552-1559
- DOI:
- 10.1093/ndt/gfac291
- PubMed:
- 36323457
NEPHROLOGY DIALYSIS TRANSPLANTATION OXFORD UNIV PRESS
Citas Recibidas en Web of Science: 6
Documentos
- No hay documentos
Filiaciones
Keywords
- diabetes; prediabetes; renal cell cancer; transplantation
Campos de Estudio
Cita
Porrini E, Pérez NM, Díaz JM, Lauzurrica R, Rodríguez JO, Torres IS, Moreso F, Garrit JMC, Ruiz RB, Vilaró MI, Lima MXM, Ramchand SK, Ruiz JC, Gainza de Los Rios F, Alvarez CR, Del Carmen M, Macías M, Vela DB, Osuna A, Bayés B, Sanchez CA, Del Carmen M, Rodríguez A, Rollán RD, Rinne FG, Sosa AJ, Mallén PD, Rinne AG, Miranda DM, Torres A. Post-transplant diabetes mellitus and renal cell cancer after renal transplantation. Nephrol Dial Transplant. 2023. 38. (6):p. 1552-1559. IF:6,100. (1).
