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  3. Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life

Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Santos-García D
  • de Deus Fonticoba T
  • Cores Bartolomé C
  • Feal Painceiras MJ
  • Íñiguez-Alvarado MC
  • García Díaz I
  • Jesús S
  • Buongiorno MT
  • Planellas L
  • Cosgaya M
  • García Caldentey J
  • Caballol N
  • Legarda I
  • Hernández Vara J
  • Cabo I
  • López Manzanares L
  • Ávila Rivera MA
  • Gómez Mayordomo V
  • Nogueira V
  • Puente V
  • Dotor García-Soto J
  • Borrué C
  • Solano Vila B
  • Álvarez Sauco M
  • Vela L
  • Escalante S
  • Cubo E
  • Carrillo Padilla F
  • Martínez Castrillo JC
  • Sánchez Alonso P
  • Alonso Losada MG
  • López Ariztegui N
  • Gastón I
  • Kulisevsky J
  • Menéndez González M
  • Seijo M
  • Ruiz Martínez J
  • Valero C
  • Kurtis M
  • González Ardura J
  • Alonso Redondo R
  • Ordás C
  • López Díaz LM
  • McAfee D
  • Calopa M
  • Carrillo F
  • Escamilla Sevilla F
  • Freire-Alvarez E
  • Gómez Esteban JC
  • García Ramos R
  • Luquín MRI
  • Martínez-Torres I
  • Sesar Ignacio Á
  • Martinez-Martin P
  • Mir P
  • COPPADIS Study Group

Unidades

Abstract

Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL: 1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05 +/- 7.84 years old; 59% males) were included. MNCD stage was: stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advanced MNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p < 0.0001) and EUROHIS-QOL8 (p < 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD.

Datos de la publicación

ISSN/ISSNe:
1877-7171, 1877-718X

JOURNAL OF PARKINSONS DISEASE  IOS PRESS

Tipo:
Article
Páginas:
379-402
PubMed:
36911948

Citas Recibidas en Web of Science: 7

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Keywords

  • Axial symptoms; MNCD classification; Parkinson's disease; cognition; non-motor symptoms; quality of life

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