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Two-Year Changes in Physical Activity and Concurrent Changes in Cognitive Function in a Cohort of Adults with Metabolic Syndrome

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Rognoni T
  • Martinez-González MÁ
  • Salas-Salvadó J
  • Corella D
  • Castañer O
  • Martínez JA
  • Alonso-Gómez ÁM
  • Gómez-Gracia E
  • Vioque J
  • Romaguera D
  • López-Miranda J
  • Estruch R
  • Tinahones FJ
  • Santos-Lozano JM
  • Serra-Majem L
  • Cano Ibañez N
  • Tur JA
  • Micó Pérez R
  • Pintó X
  • Delgado-Rodríguez M
  • Ortiz Ramos M
  • Vidal Martín J
  • Vázquez C
  • Daimiel L
  • Ros E
  • Goñi-Ruiz N
  • Babio N
  • Sorlí JV
  • Schröder H
  • García-Rios A
  • Compañ-Gabucio L
  • Warnberg J
  • Zulet MÁ
  • Chaplin A
  • Sacanella E
  • Bouzalmate-Hajjaj A
  • Tojal-Sierra L
  • Damas-Fuentes M
  • Vázquez Z
  • Gómez-Martínez C
  • Saiz C
  • Malcampo M
  • Ortiz-Morales AM
  • Martínez-Avilés V
  • García-Gavilan J
  • Abete I
  • Fitó M
  • Toledo E

Unidades

Abstract

Background: It has been proposed that physical activity (PA) could prevent cognitive decline. Objective: To evaluate the association between changes in PA and changes in cognitive function in a cohort of adults with metabolic syndrome. Methods: Longitudinal observational study including 5,500 adults (mean age 65 years, SD = 5; women = 49.3%) with metabolic syndrome. Participants underwent physical activity measurements and cognitive evaluation at baseline and at two-years of follow-up. PA was quantified using the Minnesota questionnaire-shortened version. Cognitive function was evaluated using a battery of tests: Mini-Mental Test Examination, Clock Drawing Test, Trail Making Test A and B, Verbal Fluency Test, and Digit Span. The primary outcome was two-year change in cognition, measured through the Global Composite Score (GCS) of all neuropsychological tests. Multivariable-adjusted linear regression models were fitted with baseline PA and their changes as the main exposures and changes in cognitive function as the outcome. Results: No significant association was found between PA levels (or their changes) in the GCS of cognitive function. A greater increase in PA levels was associated with a more favorable two-year change in the Trail Making Test A (Q4 versus Q1: b = -2.24s, 95% CI -4.36 to -0.12s; p-trend = 0.020). No significant association was found for other neuropsychological test. Conclusion: Our results do not support an association between increases in PA and the evolution of the global cognitive function at two-year in an intervention trial which included PA promotion in one of its two randomized arms, but they suggested a possible beneficial effect of PA on attentional function in older adults.

Datos de la publicación

ISSN/ISSNe:
1387-2877, 1875-8908

JOURNAL OF ALZHEIMERS DISEASE  SAGE PUBLICATIONS LTD

Tipo:
Article
Páginas:
887-899
PubMed:
37661880

Citas Recibidas en Web of Science: 2

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Keywords

  • Alzheimer’s disease; cognitive function; dementia; metabolic syndrome; physical activity; prevention

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