Actividad Investigadora
Safety and effectiveness of direct-acting antiviral drugs in the treatment of hepatitis C in patients with inflammatory bowel disease.
Autores de IDIVAL
Autores ajenos al IDIVAL
- Martin-Cardona A
- Horta D
- Florez-Diez P
- Vela M
- Mesonero F
- Ramos Belinchón C
- Masnou H
- de la Peña-Negro L
- Suarez Ferrer C
- Casanova MJ
- Durán MO
- Peña E
- Calvet X
- Fernández-Prada SJ
- González-Muñoza C
- Piqueras M
- Rodríguez-Lago I
- Sainz E
- Bas-Cutrina F
- Mancediño Marcos N
- Ojeda A
- Orts B
- Sicilia B
- García AC
- Domènech E
- Esteve M
- ENEIDA registry of GETECCU
Unidades
Abstract
BACKGROUND AND AIMS: Hepatitis C virus (HCV) management in Inflammatory Bowel Disease (IBD) is uncertain. The ECCO guidelines 2021 recommended HCV treatment but warn about the risk of IBD reactivation. We aimed to evaluate 1) the effectiveness and safety of direct-acting antivirals (DAAs) in IBD; 2) the interaction of DAAs with IBD drugs. METHODS: Multicentre study of IBD patients and HCV treated with DAAs. Variables related to liver diseases and IBD, as well as adverse events (AEs) and drug interactions, were recorded. McNemar's test was used to assess differences in the proportion of active IBD during the study period. RESULTS: We included 79 patients with IBD and HCV treated with DAAs from 25,998 IBD patients of the ENEIDA registry. Thirty-one (39.2 %) received immunomodulators/biologics. There were no significant differences in the percentage of active IBD at the beginning (n = 11, 13.9 %) or at the 12-week follow-up after DAAs (n = 15, 19 %) (p = 0.424). Sustained viral response occurred in 96.2 % (n = 76). A total of 8 (10.1 %) AEs occurred and these were unrelated to activity, type of IBD, liver fibrosis, immunosuppressants/biologics, and DAAs. CONCLUSIONS: We demonstrate a high efficacy and safety of DAAs in patients with IBD and HCV irrespective of activity and treatment of IBD.
Copyright © 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 1590-8658, 1878-3562
- Tipo:
- Article
- Páginas:
- 468-476
- PubMed:
- 37770282
- Enlace a otro recurso:
- www.sciencedirect.com
DIGESTIVE AND LIVER DISEASE ELSEVIER SCIENCE INC
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Filiaciones
Keywords
- Direct-acting antiviral drugs; Hepatitis C infection; Inflammatory bowel disease