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  3. Decreased oxytocin plasma levels and oxytocin receptor expression associated with aggressive behavior in aggressive-impulsive disorders

Decreased oxytocin plasma levels and oxytocin receptor expression associated with aggressive behavior in aggressive-impulsive disorders

Fecha de publicación: Fecha Ahead of Print:

Autores de IDIVAL

Autores ajenos al IDIVAL

  • Diaz-Marsá M
  • López-Villatoro JM
  • De la Torre-Luque A
  • MacDowell KS
  • Galvez-Merlin A
  • Beato-Fernández L
  • Polo-Montes F
  • León-Velasco M
  • Martín-Hernández D
  • Carrasco-Diaz A
  • Leza JC
  • Carrasco JL

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Abstract

Introduction: This study aims to enhance the understanding of the association between the phenotypic and endophenotypic characteristics of impulsive-aggressive disorders, through the study of plasma oxytocin (OXT) and oxytocin receptor (OXTR) levels in patients with borderline personality disorder (BPD) and patients with eating disorders (ED), as well as to examine the relationship of OXT system with aggressive behavior in these disorders. Methods: 68 patients with BPD, 67 patients with ED and 57 healthy control subjects were examined for plasma oxytocin levels and protein expression of OXTR in blood mononuclear cells. Aggressive behavior was assessed using the State-Trait Anger Expression Inventory (STAXI-2). Other self and hetero-aggressive behaviors were also evaluated through interviews. Results: BPD and ED patients exhibited significantly lower plasma oxytocin levels than control subjects. Furthermore, BPD patients demonstrated significantly reduced expression of OXTR compared to controls. Plasma oxytocin levels negatively correlated with verbal aggression, while OXTR expression was inversely associated with the STAXI trait subscale. Conclusions: The findings validate the existence of oxytocin system dysfunction in impulsive-aggressive disorders. They also support the link between low OXT levels in plasma and OXTR expression and the impulsive-aggressive behavior that characterizes these patients in both state and trait situations.

Copyright © 2023 Elsevier Ltd. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0022-3956, 1879-1379

JOURNAL OF PSYCHIATRIC RESEARCH  PERGAMON-ELSEVIER SCIENCE LTD

Tipo:
Article
Páginas:
200-206
PubMed:
38157667
Enlace a otro recurso:
www.sciencedirect.com

Citas Recibidas en Web of Science: 14

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Keywords

  • Borderline personality disorder; Eating disorders; Oxytocin; Aggressiveness; Impulsivity; Stress

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