Theory of Mind as an endophenotype for schizophrenia spectrum disorder: Study in first episode of psychosis patients and first-degree relatives.

Fecha de publicación: 12/10/2023 Fecha Ahead of Print: 12/10/2023

Autores de IDIVAL

Unidades

INVESTIGACIÓN EN ENFERMEDADES MENTALES

Investigador Responsable

María Rosa Ayesa Arriola

Abstract

BACKGROUND: Deficits in Theory of Mind (ToM) had been suggested as a possible endophenotype for unaffected relatives of first episode of psychosis (FEP) patients. There are a limited number of studies which have evaluated ToM deficits among the siblings and parents of FEP patients. AIM: This study aimed to explore ToM deficits and its correlates among FEP patients, their siblings, parents, and controls. METHODOLOGY: FEP patients (N=102), their parents (N=135), siblings (N=97), and controls (N=167) were evaluated on ToM performance with the Reading the Mind in the Eyes Test (Eyes Test). Interview for sociodemographic variables of age, sex, years of education, and IQ estimation and neurocognitive tests were administered to all groups. RESULTS: FEP patients had a significantly lower performance on the Eyes Test compared to their siblings and controls. However, no significant differences were found between siblings and parents or siblings and controls. CONCLUSION: Attending our results, we found no evidence for ToM deficits as an endophenotype of SSDs. Furthermore, ToM accuracy may be mediated by interaction with other cognitive domains and play a protective role against psychosis in unaffected siblings.

Datos de la publicación

ISSN/ISSNe:: 2950-2861, 2950-2853
Tipo:: Article
Páginas:: 100-105
DOI:: 10.1016/j.sjpmh.2023.09.004
PubMed:: 38591834
Enlace a otro recurso:: www.sciencedirect.com

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Filiaciones

Georgelina Abreu Fernández:: Instituto de Investigación. Research Group on Mental Illnessess, Valdecilla Biomedical Research Institute (IDIVAL)

Doctoral School University of Cantabria (EDUC)
Nancy Murillo García:: Instituto de Investigación. Research Group on Mental Illnessess, Valdecilla Biomedical Research Institute (IDIVAL)

Doctoral School University of Cantabria (EDUC)
Víctor Ortiz García de la Foz:: Instituto de Investigación. Research Group on Mental Illnessess, Valdecilla Biomedical Research Institute (IDIVAL)

Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III
Rebeca Magdaleno Herrero:: Instituto de Investigación. Research Group on Mental Illnessess, Valdecilla Biomedical Research Institute (IDIVAL)

Doctoral School University of Cantabria (EDUC)
Ángel Yorca Ruiz:: Instituto de Investigación. Research Group on Mental Illnessess, Valdecilla Biomedical Research Institute (IDIVAL)

Doctoral School University of Cantabria (EDUC)
Rosa Ayesa Arriola:: Instituto de Investigación. Research Group on Mental Illnessess, Valdecilla Biomedical Research Institute (IDIVAL)

Department of Psychiatry, University Hospital Marqués de Valdecilla

Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III