Actividad Investigadora
Effectiveness Of Tocilizumab In Aortitis And Aneurysms Associated With Giant Cell Arteritis
Autores de IDIVAL
Autores ajenos al IDIVAL
- Narváez J
- Aldasoro V
- Maiz O
- Vela P
- Romero-Yuste S
- de Miguel E
- Galíndez-Agirregoikoa E
- Fernández-López JC
- Ferraz-Amaro I
- Sánchez-Martín J
- Moya P
- Campos C
- López-Gutiérrez F
- Castañeda S
- Blanco R
- Tocilizumab in Giant Cell Arteritis Spanish Collaborative Group
Unidades
Abstract
Objective: Aortitis in Giant Cell Arteritis (GCA-aortitis) is a frequent complication that may lead to aneurysms. Tocilizumab (TCZ) was approved in GCA, but the efficacy in GCA-aortitis and aneurysms has not been analyzed to date. Our aim was to assess the effectiveness and safety of TCZ in a wide series of GCA-aortitis and aneurysms. Methods: Multicentre observational study with GCA-aortitis treated with TCZ. GCA was diagnosed by: a) ACR criteria, b) temporal artery biopsy, and/or c) imaging techniques. Aortitis was diagnosed mainly by PET/CT. Main outcomes were EULAR and imaging remission. Others were clinical remission, analytical normalization, corticosteroid-sparing effect, and the prevention and improvement of aneurysms. Results: 196 patients with GCA-aortitis treated with TCZ. After 6 months, 72.2% reached EULAR remission but only 12% an imaging remission; increasing up-to 81.4% and 31.8%, respectively, at 24 months. A rapid clinical remission, ESR and CRP normalization was observed in 47.4%, 84.3% and 55.6%, at 1 month, increasing to 89.6%, 85.3% and 80.3% at 24 months, respectively. Aneurysms were present in 10 (5%) patients. Five of them required early surgery, while 3 others enlarged. No patient on TCZ therapy developed aneurysms during follow-up. Conclusion: In patients with GCA-aortitis treated with TCZ, a rapid and maintained clinical and analytical improvement was observed. However, there was an uncoupling between clinical and EULAR remission with imaging remission.
Datos de la publicación
- ISSN/ISSNe:
- 1879-0828, 1879-0828
- Tipo:
- Article
- Páginas:
- 78-86
- PubMed:
- 38908981
European Journal of Internal Medicine ELSEVIER
Citas Recibidas en Web of Science: 14
Documentos
- No hay documentos
Filiaciones
Keywords
- Tocilizumab; Aortitis; Clinical remission; PET/ CT-remission; EULAR remission; Analytical remission; Complete remission
Campos de Estudio
Cita
Martín A, Loricera J, Narváez J, Aldasoro V, Maiz O, Vela P, Romero S, de Miguel E, Galíndez E, Fernández JC, Ferraz I, Sánchez J, Moya P, Campos C, López F, Castañeda S, Blanco R, Tocilizumab in Giant Cell Arteritis Spanish Collaborative G. Effectiveness Of Tocilizumab In Aortitis And Aneurysms Associated With Giant Cell Arteritis. Eur J Intern Med. 2024. 129. p. 78-86. IF:5,900. (1).
