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  3. Prognostic value of response to first-line hydroxyurea according to IPSET stratification in essential thrombocythemia.

Prognostic value of response to first-line hydroxyurea according to IPSET stratification in essential thrombocythemia.

Fecha de publicación: Fecha Ahead of Print:

Autores de IDIVAL

Autores ajenos al IDIVAL

  • Santaliestra M
  • Garrote M
  • Noya MS
  • Pérez-Encinas M
  • Senín A
  • Pérez-López R
  • Ferrer-Marín F
  • Carreño-Tarragona G
  • Caballero G
  • Magro E
  • Vélez P
  • Moretó A
  • Angona A
  • Pastor-Galán I
  • Guerra JM
  • García Hernández C
  • Mata MI
  • Stuckey R
  • Gómez-Casares MT
  • Fox L
  • Cuevas B
  • García-Gutiérrez V
  • Triguero A
  • Arellano-Rodrigo E
  • Hernández-Boluda JC
  • Alvarez-Larrán A

Unidades

Abstract

Hydroxyurea (HU) constitutes the first-line treatment in most patients with essential thrombocythemia (ET), but criteria for changing therapy are not clearly established. The prognostic value of complete hematological response (CHR) and resistance/intolerance to HU was assessed in 1080 patients from the Spanish Registry of ET, classified according to revised IPSET-Thrombosis stratification (Very low- n = 61, Low- n = 83, Intermediate- n = 261, and High-risk n = 675). With a median therapy duration of 5 years, CHR was registered in 720 (67%) patients (1-year probability 51%) and resistance/intolerance in 219 (20%) patients (5-years probability 13%). After correction by other risk factors, High-risk patients achieving CHR showed a reduced risk of arterial thrombosis (HR: 0.35, 95%CI: 0.2-0.6, p = 0.001) and a trend towards lower risk of venous thrombosis (HR: 0.45, 95%CI: 0.2-1.02, p = 0.06) whereas no association was observed for intermediate- or low-risk patients. In comparison with non-responders, intermediate- and high-risk patients achieving CHR had longer survival and lower myelofibrosis incidence. Development of resistance/intolerance to HU, mainly cytopenia, was associated with higher probability of myelofibrosis but no effect on survival or thrombotic risk was demonstrated. In conclusion, CHR with HU is associated with better outcomes and might be an early indicator for selecting candidates to second-line clinical trials.

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

Datos de la publicación

ISSN/ISSNe:
0887-6924, 1476-5551

LEUKEMIA  NATURE PUBLISHING GROUP

Tipo:
Article
Páginas:
2636-2643
PubMed:
39333760

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