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Novel risk loci for COVID-19 hospitalization among admixed American populations.

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Diz-de Almeida S
  • Cruz R
  • Luchessi AD
  • Lorenzo-Salazar JM
  • de Heredia ML
  • Quintela I
  • González-Montelongo R
  • Nogueira Silbiger V
  • Porras MS
  • Tenorio Castaño JA
  • Nevado J
  • Aguado JM
  • Aguilar C
  • Aguilera-Albesa S
  • Almadana V
  • Almoguera B
  • Alvarez N
  • Andreu-Bernabeu Á
  • Arana-Arri E
  • Arango C
  • Arranz MJ
  • Artiga MJ
  • Baptista-Rosas RC
  • Barreda-Sánchez M
  • Belhassen-Garcia M
  • Bezerra JF
  • Bezerra MAC
  • Boix-Palop L
  • Brion M
  • Brugada R
  • Bustos M
  • Calderón EJ
  • Carbonell C
  • Castano L
  • Castelao JE
  • Conde-Vicente R
  • Cordero-Lorenzana ML
  • Cortes-Sanchez JL
  • Corton M
  • Darnaude MT
  • De Martino-Rodríguez A
  • Del Campo-Pérez V
  • de Bustamante AD
  • Domínguez-Garrido E
  • Eirós R
  • Fernandez-Nestosa MJ
  • Fernández-Robelo U
  • Fernández-Rodríguez A
  • Fernández-Villa T
  • Gago-Dominguez M
  • Gil-Fournier B
  • Gómez-Arrue J
  • Álvarez BG
  • Bernaldo de Quirós FG
  • González-Neira A
  • González-Peñas J
  • Gutiérrez-Bautista JF
  • Herrero MJ
  • Herrero-Gonzalez A
  • Jimenez-Sousa MA
  • Lattig MC
  • Borja AL
  • Lopez-Rodriguez R
  • Mancebo E
  • Martín-López C
  • Martín V
  • Martinez-Nieto O
  • Martinez-Lopez I
  • Martinez-Resendez MF
  • Martinez-Perez A
  • Mazzeu JF
  • Macías EM
  • Minguez P
  • Cuerda VM
  • Oliveira SF
  • Ortega-Paino E
  • Parellada M
  • Paz-Artal E
  • Santos NPC
  • Pérez-Matute P
  • Perez P
  • Pérez-Tomás ME
  • Perucho T
  • Pinsach-Abuin M
  • Pita G
  • Pompa-Mera EN
  • Porras-Hurtado GL
  • Pujol A
  • León SR
  • Resino S
  • Fernandes MR
  • Rodríguez-Ruiz E
  • Rodriguez-Artalejo F
  • Rodriguez-Garcia JA
  • Ruiz-Cabello F
  • Ruiz-Hornillos J
  • Ryan P
  • Soria JM
  • Souto JC
  • Tamayo E
  • Tamayo-Velasco A
  • Taracido-Fernandez JC
  • Teper A
  • Torres-Tobar L
  • Urioste M
  • Valencia-Ramos J
  • Yáñez Z
  • Zarate R
  • de Rojas I
  • Ruiz A
  • Sánchez P
  • Real LM
  • SCOURGE Cohort Group
  • Guillen-Navarro E
  • Ayuso C
  • Parra E
  • Rojas-Martinez A
  • Flores C
  • Lapunzina P
  • Carracedo Á

Unidades

Abstract

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.

© 2024, Diz-de Almeida, Cruz et al.

Datos de la publicación

ISSN/ISSNe:
2050-084X, 2050-084X

eLife  ELIFE SCIENCES PUBLICATIONS LTD

Tipo:
Article
Páginas:
-
PubMed:
39361370

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Keywords

  • COVID-19; GWAS; SNP; genetics; genomics; none

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