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  3. OUTCOMES OF CONTROLLED DCDD LUNG TRANSPLANTATION AFTER THORACO-ABDOMINAL VS ABDOMINAL NORMOTHERMIC REGIONAL PERFUSION: THE SPANISH EXPERIENCE.

OUTCOMES OF CONTROLLED DCDD LUNG TRANSPLANTATION AFTER THORACO-ABDOMINAL VS ABDOMINAL NORMOTHERMIC REGIONAL PERFUSION: THE SPANISH EXPERIENCE.

Fecha de publicación: Fecha Ahead of Print:

Autores de IDIVAL

Autores ajenos al IDIVAL

  • Minasyan A
  • de la Torre M
  • Rodriguez JR
  • Abularach AJ
  • Román AR
  • Valentin NN
  • Serna IM
  • García PG
  • Fontana A
  • Badia GS
  • García FJG
  • Velazquez AS
  • Berjon L
  • Lera RM
  • Suarez PR
  • Coll E
  • Domínguez-Gil B
  • de la Cruz JLC

Unidades

Abstract

OBJECTIVE: Thoraco-abdominal normothermic regional perfusion (TA-NRP) has emerged as a strategy for evaluating and recovering the heart in controlled donation after the circulatory determination of death (cDCDD). However, its impact on lung grafts remains largely unknown. We aimed to assess the impact of TA-NRP on the outcomes of recipients of cDCDD lungs. METHODS: This is a retrospective, multicenter, nationwide study describing the outcomes of cDCDD lung transplants (LTs) performed in Spain from January 2021 to November 2023. Patients were divided in two groups based on the recovery technique: TA-NRP with the simultaneous recovery of the heart versus abdominal NRP (A-NRP) without simultaneous heart recovery. The primary endpoint was the incidence of Primary Graft Dysfunction (PGD) grade 3 at 72 hours. Secondary endpoints included the overall incidence of PGD, days on mechanical ventilation, ICU and hospital length of stay, early survival rates, and mid-term outcomes. RESULTS: 283 cDCDD LTs were performed during the study period, 28 (10%) using TA-NRP and 255 (90%) using A-NRP. No differences were observed in the incidence of PGD grade 3 at 72 hours between the TA-NRP and the A-NRP group (0% vs. 7.6%; p=0.231), though the overall incidence of PGD was significantly lower with TA-NRP (14.3%% vs. 41.5%; p=0.005). We found no significant differences between the groups regarding other post-transplant outcome variables. CONCLUSIONS: TA-NRP allows the simultaneous recovery of both the heart and the lungs in the cDCDD scenario with appropriate LT outcomes comparable to those observed with the A-NRP approach.

Copyright © 2024. Published by Elsevier Inc.

Datos de la publicación

ISSN/ISSNe:
1053-2498, 1557-3117

JOURNAL OF HEART AND LUNG TRANSPLANTATION  Elsevier Science Inc.

Tipo:
Article
Páginas:
697-705
PubMed:
39357781
Enlace a otro recurso:
www.sciencedirect.com

Citas Recibidas en Web of Science: 2

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Keywords

  • Donation after the circulatory determination of death; Lung transplantation; Organ donation; Thoraco-Abdominal Normothermic Regional Perfusion

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