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  3. Common mechanisms leading to mutational burden and epidermoid metaplasia for novel biomarkers of treatment in aggressive epidermoid cancer. Mecanismos moleculares comunes de carga mutacional y metaplasia epidermoide e identificación de biomarcadores en cáncer epidermoide agresivo

Common mechanisms leading to mutational burden and epidermoid metaplasia for novel biomarkers of treatment in aggressive epidermoid cancer. Mecanismos moleculares comunes de carga mutacional y metaplasia epidermoide e identificación de biomarcadores en cáncer epidermoide agresivo

Datos básicos

Código:
PI20/00880
Dotación:
244.420,00 €
Año Inicial:
2021
Año final:
2025
PROYECTO Investigación clínica NACIONAL Subvención

Objetivos del proyecto

Our final goal is to identify novel common prognostic factors and targets in squamous cancer. 1. Study of DDR determinants of epidermoid cancer in vivo. 2. Mechanisms of epidermoid metaplasia in simple epithelia of the lung and the mammary gland. 3. Validation of genes controlling the DMC as markers of epidermoid aggressiveness. 4. Gene searches for common biomarkers and targets in epidermoid cancer

Unidades de investigación

Documentos

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Financiadores

INSTITUTO DE SALUD CARLOS III.

Resultados del Proyecto

Extract From the Leaves of Polypodium Leucotomos Stimulates DNA Repair Signals ?H2AX and P53 to Prolong the Keratinocyte DNA Repair Phase of the Cell Cycle

Article. 2023


Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint

Article. 10.1038/s41419-024-06969-z. 2024

  • Open Access.

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