Tratamiento con fosfomicina de las infecciones urinarias por Klebsiella pneumoniae en el receptor de trasplante renal. Impacto del pH urinario y bajo nivel de resistencia. Fosfomycin treatment of Klebsiella pneumoniae urinary tract infections in kidney transplant recipients. Impact of urine pH and low level resistance

Datos básicos

Código:

FIS-FOS-2020-01

Protocolo:

FIS-FOS-2020-01

EUDRACT:

NCT:

Centro:

HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA

Dotación:

Año de incio:

2021

Año de finalización:

Objetivos del proyecto

General objective To study the outcome of K. pneumoniae infections in kidney recipients treated with fosfomycin and the impact of LLFR and pH in the outcome of these infections Specific objectives 1. To study the incidence, phenotypic and genotypic characteristics of lower urinary tract infections by K. pneumoniae, susceptible or with low level resistance to fosfomycin, in KTR. 2. To analyze the clinical and microbiological evolution of lower UTI by K. pneumoniae in KTR treated with fosfomycin, according to the urinary pH. 3. To analyze the development of high resistance mutants after the treatment with fosfomycin in patients with lower UTI by LLFR K. pneumoniae strains. 4. To study the mutations in LLFR and fosfomycin-resistant mutants by whole genome sequencing. 5. To study the microbiological efficacy and development of high level resistance mutations after treatment with fosfomycin in a murine model of ITU by K. pneumoniae susceptible to fosfomycin and with LLFR and its relationship with urinary pH.

Unidades de investigación

• ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLÍNICA

  

  Investigador Responsable

  María Del Carmen Fariñas Álvarez

  mcarmen.farinas@scsalud.es

• INMUNOPATOLOGÍA

  

  Investigador Corresponsable

  Ricardo Blanco Alonso

  ricardo.blanco@scsalud.es