Actividad Investigadora
Shannon entropy as a reliable score to diagnose human fibroelastic degenerative mitral chords: A micro-ct ex-vivo study
Fecha de publicación:
Fecha Ahead of Print:
Autores de IDIVAL
Autores ajenos al IDIVAL
- Sainz-Aja, JA
- Wert-Carvajal, C
- Casado, JA
- Diego, S
- Carrascal, IA
- Silva, J
- Gutierrez-Solana, F
Abstract
This paper is aimed at identifying by means of micro-CT the microstructural differences between normal and degenerative mitral marginal chordae tendineae. The control group is composed of 21 normal chords excised from 14 normal mitral valves from heart transplant recipients. The experimental group comprises 22 degenerative fibroelastic chords obtained at surgery from 11 pathological valves after mitral repair or replacement. In the control group the superficial endothelial cells and spongiosa layer remained intact, covering the wavy core collagen. In contrast, in the experimental group the collagen fibers were arranged as straightened thick bundles in a parallel configuration. 100 cross-sections were examined by micro-CT from each chord. Each image was randomized through the K-means machine learning algorithm and then, the global and local Shannon entropies were obtained. The optimum number of clusters, K, was estimated to maximize the differences between normal and degenerative chords in global and local Shannon entropy; the p-value after a nested ANOVA test was chosen as the parameter to be minimized. Optimum results were obtained with global Shannon entropy and 2 <= K <= 7, providing p < 0.01; for K=3, p = 2.86.10(-3). These findings open the door to novel perioperative diagnostic methods in order to avoid or reduce postoperative mitral valve regurgitation recurrences.
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 1350-4533, 1873-4030
- Tipo:
- Article
- Páginas:
- 103919-103919
- PubMed:
- 36564142
- Factor de Impacto:
- 0,000 SCImago ℠
MEDICAL ENGINEERING & PHYSICS ELSEVIER SCI LTD
Citas Recibidas en Web of Science: 1
Documentos
- No hay documentos
Filiaciones
Keywords
- Degenerative mitral valve disease; K-means; Machine learning; Micro computerized tomography; Mitral chordae tendineae; Shannon entropy
Campos de Estudio
Proyectos asociados
Diagnóstico de cuerdas tendinosas de la válvula mitral humana mediante análisis multi-enfoque: óptico, mecánico, micro-estructural y anatómico (DICUTEN)
Investigador Principal: Olga María Conde Portilla
INNVAL16/02 . FUNDACION INSTITUTO DE INVESTIGACION MARQUES DE VALDECILLA . 2017
Cita
Ferreno D, REVUELTA JM, Sainz JA, Wert C, Casado JA, Diego S, Carrascal IA, Silva J, Gutierrez F. Shannon entropy as a reliable score to diagnose human fibroelastic degenerative mitral chords: A micro-ct ex-vivo study. Med. Eng. Phys. 2022. 110. p. 103919-103919. IF:2,356. (3).
