Actividad Investigadora
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
Fecha de publicación:
Autores de IDIVAL
Autores ajenos al IDIVAL
- Balagué-Dobón, L
- Esko, T
- de Heredia, ML
- Abellán, J
- Acosta-Isaac, R
- AGUADO, JM
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- Sabbagh, AA
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- Albu, S
- Alcalá-Gallardo, KAM
- Alcoba-Florez, J
- Batres, SA
- Algarin-Lara, HR
- Almadana, V
- Medeiros, KA
- Almeida, J
- Almoguera, B
- Alonso, MR
- Alvarez, N
- Walther, RAS
- Alvarez-Benítez, Y
- Alvarez-Navia, F
- dos Santos, KA
- Andreu-Bernabeu, A
- Antonijoan, MR
- Martínez-Aquino, E
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- López, JRA
- Artiga, MJ
- Avello-Malaver, Y
- Ayuso, C
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- Brion, M
- Brochado-Kith, O
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- Cabello, A
- Cáceres, A
- Cáceres-Agra, JJ
- Calbo, E
- Calderón, EJ
- Camacho, S
- Ceballos, FC
- Cañadas, Y
- Carbonell, C
- Cardona-Huerta, S
- Abad, MSC
- Segura, CC
- Carrillo-Avila, JA
- Campos, MC
- Casasnovas, C
- Castaño, L
- Castaño, CF
- Castelao, JE
- Candalija, AC
- Castillo, MA
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- Cunha, GCR
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- Corella, D
- Cortés-Sánchez, JL
- Corton, M
- Souza, KSC
- Silva, FTC
- Cruz, R
- Cuesta, L
- Tavares, NAC
- Carvalho, MCC
- Dalmau, D
- Dantas-Komatsu, RCS
- Darnaude, MT
- de Andrés, R
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- Troca, JJD
- de la Horra, C
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- Cruz, MS
- Neri, JLDA
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- Sanabria, GE
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- de Araújo, JNG
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- Jacomo, RH
- Hernández, E
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- Valido, A
- Vargas-Gallo, JP
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- Velasco-Quirce, S
- Vélez-Santamaría, V
- Víctor, V
- Vidán-Estévez, J
- Silva, GV
- Vieitez-Santiago, M
- Vilches, C
- Villalobos, L
- Villar, F
- Villar-Garcia, J
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- Villoslada-Blanco, P
- Virseda-Berdices, A
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- Yáñez, Z
- Zapatero-Gaviria, A
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- Zazo, S
- Flores, C
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- Lapunzina, P
- Carracedo, A
- González, JR
- SCOURGE Cohort Grp
Abstract
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality.
Datos de la publicación
- ISSN/ISSNe:
- 2399-3642, 2399-3642
- Tipo:
- Article
- Páginas:
- -
Communications Biology NATURE PUBLISHING GROUP
Citas Recibidas en Web of Science: 99
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