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Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors

Fecha de publicación: Fecha Ahead of Print:

Autores de IDIVAL

Autores ajenos al IDIVAL

  • Rodrigues-Diez R
  • Ballesteros-Martinez C
  • Moreno-Carriles RM
  • Díaz Del Campo LS
  • Cachofeiro V
  • Dalli J
  • García-Redondo AB
  • Redondo JM
  • Salaices M
  • Briones AM

Unidades

Abstract

During resolution of inflammation, specialized proresolving mediators (SPMs), including resolvins, are produced to restore tissue homeostasis. We hypothesized that there might be a dysregulation of SPMs pathways in pathological vascular remodeling and that resolvin D2 (RvD2) might prevent vascular remodeling and contractile and endothelial dysfunction in a model of obesity and hypertension. In aortic samples of patients with or without abdominal aortic aneurysms (AAA), we evaluated gene expression of enzymes involved in SPMs synthesis (ALOXs), SPMs receptors and pro-inflammatory genes. In an experimental model of aortic dilation induced by high fat diet (HFD, 60%, eighteen weeks) and angiotensin II (AngII) infusion (four weeks), we studied the effect of RvD2 administration in aorta and small mesenteric arteries structure and function and markers of inflammation. In human macrophages we evaluated the effects of AngII and RvD2 in macrophages function and SPMs profile. In patients, we found positive correlations between AAA and obesity, and between AAA and expression of ALOX15, RvD2 receptor GPR18, and pro-inflammatory genes. There was an inverse correlation between the expression of aortic ALOX15 and AAA growth rate. In the mice model, RvD2 partially prevented the HFD plus

Datos de la publicación

ISSN/ISSNe:
0753-3322, 1950-6007

BIOMEDICINE & PHARMACOTHERAPY  ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Tipo:
Article
Páginas:
116564-116564
PubMed:
38608525

Citas Recibidas en Web of Science: 3

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Keywords

  • Resolvin D2; vascular remodeling; Endothelial dysfunction; Hypertension; Obesity; Resolution of inflammation

Campos de Estudio

Financiación

Comunidad de Madrid (FIS PI21/00084)
ERDF A way of making Europe
European Research Council under the European Union (IJCI-2017-31399)
European Union (677542)
FEDER-a way to build Europe (677542)
FUNDACION INSTITUTO DE INVESTIGACION MARQUES DE VALDECILLA (INNVAL21/24)
IDIVAL (954798)
IDIVAL (IJCI-2017-31399)
Juan de la Cierva
MCIN/AEI (B2017/BMD-3676 AORTASANA)
MCIN/AEI (PID2021-122388OB-100)
MCIN/AEI (SAF2016-80305P)
PID2020-116498RB-I00

Proyectos asociados

Transcriptómica e inteligencia artificial para la predicción de remodelado cardiaco desfavorable en pacientes operados por estenosis valvular aórtica

Investigador Principal: Juan Francisco Nistal Herrera

INNVAL21/24 . FUNDACION INSTITUTO DE INVESTIGACION MARQUES DE VALDECILLA . 2021

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