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Differences in circulating alpha-calcitonin gene-related peptide levels in inflammatory bowel disease and its relation to migraine comorbidity: A cross-sectional study

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Abstract

ObjectiveTo analyze the specificity of calcitonin gene-related peptide (CGRP) levels, we measured alpha-CGRP circulating levels in a large series of patients with a recent diagnosis of inflammatory bowel disease (IBD) who were interviewed regarding comorbid headache. BackgroundSeveral studies have found an association between migraine and IBD. MethodsIn this cross-sectional study performed in an IBD clinic, morning serum alpha-CGRP levels were measured by enzyme-linked immunosorbent assay in 96 patients who were recently diagnosed with IBD and compared to those from 50 similar patients with chronic migraine (CM) and 50 healthy controls (HC). ResultsAlpha-CGRP levels were higher in patients with IBD (median [interquartile range] 56.9 [35.6-73.9] pg/mL) and patients with CM (53.0 [36.7-73.9] pg/mL) compared to HC (37.2 [30.0-51.8] pg/mL; p = 0.003; p = 0.019, respectively). Regarding IBD diagnostic subtypes, alpha-CGRP levels for ulcerative colitis (67.2 +/- 49.3 pg/mL; 57.0 [35.6-73.4] pg/mL) and Crohn's disease (54.9 +/- 27.5 pg/mL; 57.7 [29.1-76.1] pg/mL) were significantly higher than those of HC (p = 0.013, p = 0.040, respectively). Alpha-CGRP levels were further different in patients with IBD with migraine (70.9 [51.8-88.7] pg/mL) compared to HC (p < 0.001), patients with IBD without headache (57.5 [33.3-73.8] pg/mL; p = 0.049), and patients with IBD with tension-type headache but without migraine (41.7 [28.5-66.9] pg/mL; p = 0.004), though alpha-CGRP levels in patients with IBD without migraine (53.7 [32.9-73.5] pg/mL) remained different over HC (p = 0.028). ConclusionTogether with CM, circulating alpha-CGRP levels are different in patients with IBD, perhaps reflecting a chronic inflammatory state. IBD is an example of how alpha-CGRP levels are not a totally specific migraine biomarker. However, alpha-CGRP levels were further increased in patients with IBD who have a history of migraine, which reinforces its role as a biomarker in migraine patients, always bearing in mind their comorbidities. Plain Language Summary Alpha-calcitonin gene-related peptide (CGRP) levels may be a potential migraine biomarker, but it is unclear if this is the case because changes in CGRP concentrations can also be present in other conditions. We measured morning serum alpha-CGRP levels in 96 patients with a recent inflammatory bowel disease (IBD) diagnosis, and compared them to 50 matched healthy participants and 50 matched patients with chronic migraine (CM). We found a significant increase in serum alpha-CGRP levels in both patients with IBD and CM compared to healthy controls, which we think may reflect chronic inflammation found in IBD; these results offer another example that alpha-CGRP concentrations are not totally specific for migraine.

Datos de la publicación

ISSN/ISSNe:
1526-4610, 1526-4610

HEADACHE  WILEY

Tipo:
Article
Páginas:
849-858
PubMed:
38922858

Citas Recibidas en Web of Science: 6

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Keywords

  • alpha-calcitonin gene-related peptide; calcitonin gene-related peptide; chronic migraine; Crohn's disease; inflammatory bowel disease; ulcerative colitis

Campos de Estudio

Proyectos asociados

Especificidad y sensibilidad de los niveles de CGRP: análisis a fondo de su estado en migraña, otras cefaleas primarias y secundarias y en enfermedades inflamatorias sistémicas

Investigador Principal: Julio Pascual Gómez

PI20/01358 . INSTITUTO DE SALUD CARLOS III. . 2021

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