Actividad Investigadora
Especificidad y sensibilidad de los niveles de CGRP: análisis a fondo de su estado en migraña, otras cefaleas primarias y secundarias y en enfermedades inflamatorias sistémicas
Datos básicos
Objetivos del proyecto
1. Analizar en detalle en un grupo de controles la influencia de diferentes aspectos/variables metodológicas externas e internas en los niveles de CGRP total, CGRPalfa y CGRPbeta. 2. Analizar CGRP, CGRPalfa y CGRPbeta en pacientes con cefalea en racimos y arteritis temporal (como ejemplos de cefalea primaria y secundaria en las que el CGRP podría también jugar un papel en su fisiopatología). 3. Determinar los niveles de CGRP, CGRPalfa y CGRPbeta en pacientes con enfermedades inflamatorias sistémicas: artritis sin tratamiento, psoriasis y enfermedad inflamatoria intestinal. 4. Estudiar los niveles CGRP, CGRPalfa y CGRPbeta antes y 2 semanas y 4 semanas después del tratamiento con anticuerpos anti-CGRP y correlacionar estos niveles con la respuesta al tratamiento y la posible aparición de efectos adversos.
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Resultados del Proyecto
Alpha and beta-CGRP levels in inflammatory bowel diseases and its association with migraine: the importance of discriminate isoforms
Garate, G.; (...); Pascual, J.
Meeting Abstract. 2024
Alpha-CGRP as a specific response mediator during acute myocardial infarction in humans: findings from an observational longitudinal study.
Gárate G; (...); González-Quintanilla V
Article. 10.3389/fcvm.2025.1581056. 2025
Analysis of serum alpha-CGRP levels in different disorders and its meaning regarding the specificity of increased concentrations of the peptide for chronic migraine
Gárate, G; (...); Pascual, J
Meeting Abstract. 2025
Beta-CGRP in inflammatory bowel disease: a protective neuropeptide of the gut
Pascual, M.; (...); Rivero Tirado, M.
Meeting Abstract. 10.1093/ecco-jcc/jjad212.0307. 2024
Both receptor and circulating monoclonal antibodies selectively normalize baseline increased serum alpha-CGRP levels in chronic migraine patients throughout 3-month treatment
Gárate, G; (...); Pascual, J
Meeting Abstract. 2023
Calcitonin gene-related peptide (CGRP) in the pathophysiology of gastrointestinal disorders - A key mediator in the gut-brain axis.
Pascual-Mato M; (...); Pascual Gómez J
Article. 10.17235/reed.2025.11310/2025. 2025
Differences in circulating alpha-calcitonin gene-related peptide levels in inflammatory bowel disease and its relation to migraine comorbidity: A cross-sectional study
Pascual-Mato M; (...); Pascual J
Article. 10.1111/head.14768. 2024
Evaluating the chameleon role of beta-CGRP in gastrointestinal disorders and migraine patients with constipation due to anti-CGRP/CGRPr monoclonal antibodies
Pascual, M; (...); Pascual, J
Meeting Abstract. 2023
Increased prevalence of migraine in women with inflammatory bowel disease: A cross-sectional study
Pascual-Mato M; (...); Rivero M
Article. 10.1177/03331024241233979. 2024
Increased prevalence of migraine in women with inflammatory bowel disease: a cross-sectional study
Pascual, M; (...); Tirado, MR
Meeting Abstract. 2024
Low serum 25-hydroxyvitamin D levels in migraine are not related to headache frequency: A case-control study in patients with high-frequency/chronic migraine.
Haro M; (...); Pascual J
Article. 10.1111/head.14901. 2025
Plasma with Added Protease Inhibitors Improves Alpha- and Beta-CGRP Measurement Compared to Serum: Towards a Reliable Biomarker for Chronic Migraine
de la Guerra-sasián, L; (...); Martín, MMS
Article. 10.3390/ijms26209958. 2025
Serum alpha and beta-CGRP levels in chronic migraine patients before and after CGRP monoclonal antibodies
Pascual, J; (...); Madera, J
Meeting Abstract. 2023
Serum CGRPalpha and beta levels are increased in COVID-19 inpatients
Garate, G; (...); Pascual, J
Meeting Abstract. 2022
Unravelling the role of beta-CGRP in inflammatory bowel disease and its potential role in gastrointestinal homeostasis
Pascual-Mato M; (...); Rivero M
Article. 10.1186/s12876-024-03366-w. 2024
Untangling the mess of CGRP levels as a migraine biomarker: an in-depth literature review and analysis of our experimental experience
Gárate G; (...); González-Quintanilla V
Article. 10.1186/s10194-024-01769-4. 2024
