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Alpha-CGRP as a specific response mediator during acute myocardial infarction in humans: findings from an observational longitudinal study.

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Abstract

INTRODUCTION: Calcitonin gene-related peptide (CGRP), particularly its alpha isoform, might play a role in restoring physiological cardiovascular functioning. While its involvement in acute myocardial infarction (AMI) pathophysiology has been suggested, human data remain scarce. This study analyzed circulating alpha-CGRP levels during AMI, comparing them to healthy controls (HC) and post-AMI resolution levels. METHODS: A total of 26 AMI patients and 26 age- and sex-matched HC were recruited. Blood samples were collected from patients within four hours of AMI onset and, when possible, six months post-event. Alpha-CGRP serum concentrations were measured using a validated ELISA assay. RESULTS: Alpha-CGRP levels were significantly higher in AMI patients at admission (mean ± SD: 96.0 ± 77.4 pg/ml) compared to HC (42.0 ± 25.8 pg/ml, p < 0.0001), with an average increase of 129%. Among nine patients available for follow-up, levels normalized to the HC range (45.1 ± 26.7 pg/ml, p = 0.011). Patients with poor outcomes had numerically lower alpha-CGRP levels (72.6 ± 37.2 pg/ml) than those with a satisfactory resolution (100.3 ± 82.5 70.6 pg/ml; p = 0.241). DISCUSSION: Alpha-CGRP is acutely elevated during AMI, likely as a compensatory vasodilator response to ischemia. Its post-AMI normalization suggests a transient protective mechanism. Further research is needed to explore its role in AMI-related pathophysiology and usefulness as a therapeutic agent.

© 2025 Gárate, Gangas, de la Torre, Muñoz San-Martín, Pascual and González-Quintanilla.

Datos de la publicación

ISSN/ISSNe:
2297-055X, 2297-055X

Frontiers in Cardiovascular Medicine  FRONTIERS MEDIA SA

Tipo:
Article
Páginas:
1581056-1581056
PubMed:
40589453

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Keywords

  • alpha-CGRP; biomarker; cardiac cephalgia; myocardial infarction; response mediator

Campos de Estudio

Proyectos asociados

Especificidad y sensibilidad de los niveles de CGRP: análisis a fondo de su estado en migraña, otras cefaleas primarias y secundarias y en enfermedades inflamatorias sistémicas

Investigador Principal: Julio Pascual Gómez

PI20/01358 . INSTITUTO DE SALUD CARLOS III. . 2021

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