Management of multidrug-resistant gram-negative bacilli infections in adult solid organ transplant recipients: GESITRA-IC/SEIMC, CIBERINFEC, and SET recommendations update.

Fecha de publicación: 21/05/2025 Fecha Ahead of Print: 21/05/2025

Autores de IDIVAL

David Iturbe Fernández

Autor

Autores ajenos al IDIVAL

Rodríguez-Goncer I
Ruiz-Arabi E
Herrera S
Sabé N
Los-Arcos I
Silva JT
Pérez-Nadales E
Machuca I
Álvarez R
Valerio M
Castón JJ
Aguilera V
Bodro M
Cano Á
Cantón R
Carmona P
Carratalà J
Cordero E
Cruzado JM
Fariñas MC
Fernández-Ruiz M
Fondevila C
Fortún J
García-Cosío MD
Gutiérrez-Dalmau A
Justo I
Len O
López-Medrano F
López Oliva MO
Martín-Dávila P
Martínez-Martínez L
Mazuecos A
Mirabet S
Muñoz P
Oliver A
Pérez-Sáez MJ
Rodríguez-Gómez J
San-Juan R
Sánchez-Céspedes J
Solé A
Vidal Verdú E
Villa J
Torre-Cisneros J
Aguado JM

Unidades

INMUNOPATOLOGÍA

Abstract

Multidrug-resistant (MDR) Gram-negative bacilli (GNB) infections in solid organ transplant (SOT) recipients continue to pose a significant threat despite advances in diagnostics and treatments. The last international consensus guidelines of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the management of MDR GNB in adult solid organ transplant (SOT) recipients were published in 2018, underscoring the need for an update to incorporate recent advances, particularly the availability of new drugs that may improve the current standard of care. A working group consisting of members from the Study Group of Infection in Transplantation and Immunocompromised Hosts (GESITRA-IC) of SEIMC, the Center for Biomedical Research Network in Infectious Diseases (CIBERINFEC) and the Spanish Society of Transplantation (SET) developed consensus-based recommendations for managing MDR GNB infections during the transplant procedure. Recommendations were categorized based on evidence quality and strength, utilizing the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The final recommendations were endorsed through a consensus meeting and approved by the expert panel.

Datos de la publicación

ISSN/ISSNe:: 0955-470X, 1557-9816
Tipo:: Article
Páginas:: 100937-100937
DOI:: 10.1016/j.trre.2025.100937
PubMed:: 40414085

Documentos

No hay documentos

Métricas

Filiaciones

Rodríguez-Goncer I:: Unit of Infectious Diseases, University Hospital "12 de Octubre", Biomedical Research Institute Hospital "12 de Octubre" (i+12), Madrid, Spain

Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

School of Medicine, Universidad Complutense, Madrid, Spain
Ruiz-Arabi E:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Service of Infectious Diseases, Reina Sofia University Hospital, Spain

Maimonides Institute for Biomedical Research (IMIBIC), University of Cordoba, Cordoba, Spain
Herrera S:: Infectious Diseases Department. Transplant Coordination Service. Hospital Clínic, University of Barcelona, August Pi i Sunyer Biomedical Research Institute Barcelona (IDIBAPS), Spain
Sabé N:: Infectious Diseases Department, Bellvitge University Hospital, Bellvitge. Biomedical Research Institute (IDIBELL), University of Barcelona, L'Hospitalet de llobregat, Barcelona, Spain
Los-Arcos I:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain
Silva JT:: Unit of Infectious Diseases, University Hospital "12 de Octubre", Biomedical Research Institute Hospital "12 de Octubre" (i+12), Madrid, Spain

Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain
Pérez-Nadales E:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Service of Infectious Diseases, Reina Sofia University Hospital, Spain

Maimonides Institute for Biomedical Research (IMIBIC), University of Cordoba, Cordoba, Spain

Department of Agricultural Chemistry, Soil Science and Microbiology, University of Cordoba, Córdoba, Spain
Machuca I:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Service of Infectious Diseases, Reina Sofia University Hospital, Spain

Maimonides Institute for Biomedical Research (IMIBIC), University of Cordoba, Cordoba, Spain
Álvarez R:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Clinical Unit of Infectious Diseases, Microbiology and Parasitology. Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital/CSIC/University of Seville, Seville, Spain
Valerio M:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

School of Medicine, Universidad Complutense, Madrid, Spain

Microbiology Department. Hospital Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Spain
Castón JJ:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Service of Infectious Diseases, Reina Sofia University Hospital, Spain

Maimonides Institute for Biomedical Research (IMIBIC), University of Cordoba, Cordoba, Spain
Aguilera V:: Liver Transplantation and Hepatology Unit, Hospital Universitari i Politécnic La Fe, Valencia, Spain

Center for Biomedical Research in Liver and Digestive Diseases (CIBERehd). Instituto de Salud Carlos III, Spain
Bodro M:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Infectious Diseases Department. Transplant Coordination Service. Hospital Clínic, University of Barcelona, August Pi i Sunyer Biomedical Research Institute Barcelona (IDIBAPS), Spain
Cano Á:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Service of Infectious Diseases, Reina Sofia University Hospital, Spain
Cantón R:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Microbiology Department, Ramón y Cajal University Hospital. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
Carmona P:: Intensive Care Medicine Unit. Reina Sofía University Hospital, Córdoba, Spain
Carratalà J:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Infectious Diseases Department, Bellvitge University Hospital, Bellvitge. Biomedical Research Institute (IDIBELL), University of Barcelona, L'Hospitalet de llobregat, Barcelona, Spain
Cordero E:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Clinical Unit of Infectious Diseases, Microbiology and Parasitology. Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital/CSIC/University of Seville, Seville, Spain

Department of Medicine, Faculty of Medicine, Universidad de Sevilla, Spain
Cruzado JM:: Nephrology Department, Bellvitge Hospital. University of Barcelona. Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
Fariñas MC:: Instituto de Investigación. Infectious Diseases Department, Hospital Universitario Marqués de Valdecilla. Instituto de Investigación Marqués de Valdecilla (IDIVAL). Universidad de Cantabria. Santander, Cantabria, Spain
Fernández-Ruiz M:: Unit of Infectious Diseases, University Hospital "12 de Octubre", Biomedical Research Institute Hospital "12 de Octubre" (i+12), Madrid, Spain

Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

School of Medicine, Universidad Complutense, Madrid, Spain
Fondevila C:: General and Digestive Surgery Department, Hospital Universitario La Paz, IdiPAZ, CIBERehd, Madrid, Spain
Fortún J:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Infectious Diseases Department, Ramón y Cajal University Hospital. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
García-Cosío MD:: Cardiology Department. University Hospital "12 de Octubre". Biomedical Research Institute Hospital "12 de Octubre" (i+12), Madrid, Spain

Center for Biomedical Research in Cardiovascular Diseases (CIBERCV), Spain
Gutiérrez-Dalmau A:: Kidney Transplant Unit, Nephrology Service, Miguel Servet University Hospital, Aragón Institute for Health Research IIS-Aragón, Zaragoza, Spain
Iturbe D:: Instituto de Investigación. Respiratory Medicine Department, Hospital Universitario Marqués de Valdecilla. Instituto de Investigación Marqués de Valdecilla (IDIVAL). Universidad de Cantabria. Santander, Cantabria, Spain
Justo I:: Unit of Hepato-Pancreato-Biliary Surgery and Abdominal Organ Transplantation, University Hospital "12 de Octubre", Biomedical Research Institute Hospital "12 de Octubre" (i+12). Department of Surgery, Faculty of Medicine, Complutense University, Madrid, Spain
Len O:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain
López-Medrano F:: Unit of Infectious Diseases, University Hospital "12 de Octubre", Biomedical Research Institute Hospital "12 de Octubre" (i+12), Madrid, Spain

Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

School of Medicine, Universidad Complutense, Madrid, Spain
López Oliva MO:: Nephrology Department, Hospital Universitario La Paz, Madrid, Spain
Martín-Dávila P:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Infectious Diseases Department, Ramón y Cajal University Hospital. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
Martínez-Martínez L:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Maimonides Institute for Biomedical Research (IMIBIC), University of Cordoba, Cordoba, Spain

Department of Agricultural Chemistry, Soil Science and Microbiology, University of Cordoba, Córdoba, Spain

Microbiology Unit, Reina Sofía University Hospital, Cordoba, Spain
Mazuecos A:: Kidney Transplant Unit. Department of Nephrology, Hospital Universitario Puerta del Mar, Cadiz, Spain
Mirabet S:: Center for Biomedical Research in Cardiovascular Diseases (CIBERCV), Spain

Heart Transplantation Unit, Cardiology Department, Hospital Sant Pau, Barcelona, Spain
Muñoz P:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

School of Medicine, Universidad Complutense, Madrid, Spain

Microbiology Department. Hospital Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Spain
Oliver A:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Microbiology Department, Hospital Universitario Son Espases, Health Research Institute of Balearic Islands (IdISBa), Palma de Mallorca, Spain
Pérez-Sáez MJ:: Kidney Transplant Unit, Nephrology Department, Hospital del Mar. Hospital del Mar Research Institute. RICORS 2040-Renal, Barcelona, Spain
Rodríguez-Gómez J:: Intensive Care Medicine Unit. Reina Sofía University Hospital, Córdoba, Spain
San-Juan R:: Unit of Infectious Diseases, University Hospital "12 de Octubre", Biomedical Research Institute Hospital "12 de Octubre" (i+12), Madrid, Spain

Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

School of Medicine, Universidad Complutense, Madrid, Spain
Sánchez-Céspedes J:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Clinical Unit of Infectious Diseases, Microbiology and Parasitology. Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital/CSIC/University of Seville, Seville, Spain
Solé A:: Lung Transplant Unit, Hospital Universitari i Politècnic La Fe, Valencia, Spain
Vidal Verdú E:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Service of Infectious Diseases, Reina Sofia University Hospital, Spain
Villa J:: School of Medicine, Universidad Complutense, Madrid, Spain

Microbiology Department, University Hospital "12 de Octubre", Biomedical Research Institute Hospital "12 de Octubre" (i+12), Madrid, Spain
Torre-Cisneros J:: Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

Service of Infectious Diseases, Reina Sofia University Hospital, Spain

Maimonides Institute for Biomedical Research (IMIBIC), University of Cordoba, Cordoba, Spain
Aguado JM:: Unit of Infectious Diseases, University Hospital "12 de Octubre", Biomedical Research Institute Hospital "12 de Octubre" (i+12), Madrid, Spain

Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain

School of Medicine, Universidad Complutense, Madrid, Spain

Keywords

Gram-negative bacilli; Management; Multidrug resistance; Prevention; Solid organ transplantation

Campos de Estudio

Cita

Cita Bibliográfica