Actividad Investigadora
Role of <i>IRF5</i> in the pathogenesis of immunoglobulin-A vasculitis
Autores de IDIVAL
Autores ajenos al IDIVAL
- Remuzgo-Martinez, S
- Llorca, J
- Sevilla-Perez, B
- Ortego-Centeno, N
- Lera-Gomez, L
- Leonardo, MT
- Penalba, A
- Miranda-Filloy, JA
- Parejo, AN
- Perez, JS
- de Argila, D
- Rubio, E
- Luque, ML
- Blanco-Madrigal, JM
- Galindez-Agirregoikoa, E
- Gualillo, O
- Martin, J
- Castaneda, S
- Gonzalez-Gay, MA
Unidades
Abstract
Objective. Interferon regulatory factor 5 (IRF5) is a major regulator of type I interferon induction and is also critical to produce pro-inflammatory cytokines. An influence of IRF5 genetic variants on the increased risk of immune-mediated diseases has been described. Accordingly, we aimed to evaluate the implication of IRF5 in the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular pathology. Methods. Three tag genetic variants (rs2004640, rs2070197 and rs10954213),representative of 3 different haplotve blocks within IRF5, were genotyped in 372 Caucasian patients with IgAV and 876 sex and ethnically matched healthy controls by TaqMan assays. Results. No significant differences in the genotype and allele,frequencies between patients with IgAV and healthy controls were observed when each IRF5 polymorphism was evaluated independently. Likewise, no significant differences between patients with IgAV and healthy controls were found when we assessed the three IRE:5 polymorphisms combined, conforming haplotypes. In addition, there were no significant differences in genotype, allele and haplotype frequencies of IRE:5 when patients with IgAV were stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations. Conclusion. Our results do not support an influence of IRF5 on the pathogenesis of IgAV.
Filiaciones
Keywords
- IgA; vasculitis; IRF5
