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Increased risk of MAFLD and Liver Fibrosis in Inflammatory Bowel Disease Independent of Classic Metabolic Risk Factors

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Calleja JL
  • Hernández-Conde M
  • Vera MI
  • Frias Y

Unidades

Abstract

BACKGROUND & AIMS: There is conflicting evidence regarding the prevalence of and risk factors for metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel disease (IBD). We aimed to determine MAFLD prevalence and risk factors in IBD patients.METHODS: Cross-sectional, case-control study included all consecutive IBD patients treated at 2 different university hospitals. Controls were subjects randomly selected from the general population and matched by age, sex, type 2 diabetes status, and body mass index in a 1:2 ratio. MAFLD was confirmed by controlled attenuation parameter. Liver biopsies were collected when MAFLD with significant liver fibrosis was suspected. In addition, age-and fibrosis stage-paired non-IBD patients with biopsy-proven MAFLD served as a secondary control group.RESULTS: Eight hundred thirty-one IBD patients and 1718 controls were included. The prevalence of MAFLD and advanced liver fibrosis (transient elastography double dagger 9.7 kPa) was 42.00% and 9.50%, respectively, in IBD patients and 32.77% and 2.31%, respectively, in the general population (P < .001). A diagnosis of IBD was an independent predictor of MAFLD (adjusted odds ratio, 1.99; P < .001) and an independent risk factor for advanced liver fibrosis (adjusted odds ratio, 5.55; P < .001). Liver biopsies were obtained from 40 IBD patients; MAFLD was confirmed in all cases, and fibrosis of any degree was confirmed in 25 of 40 cases (62.5%). Body mass index and type 2 diabetes prevalence were significantly lower in IBD-MAFLD patients than in severity-paired patients with biopsy-proven MAFLD. CONCLUSIONS: MAFLD and liver fibrosis are particularly prevalent in IBD patients, regardless of the influence of classic metabolic risk factors.

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
1542-3565, 1542-7714

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association  ELSEVIER SCIENCE INC

Tipo:
Article
Páginas:
406-4147
PubMed:
35124272
Enlace a otro recurso:
www.sciencedirect.com

Citas Recibidas en Web of Science: 41

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Keywords

  • MAFLD; Inflammatory Bowel Disease; Liver Fibrosis; Metabolic Syndrome

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