Increased risk of early lung function alterations in people with psychosis: A cross-sectional case-control study.

Autores de IDIVAL

• Ana Fátima Viejo Casas

  Autor

• 

  Carlos Antonio Amado Diago

  Autor

• Jesús Agüero Balbín

  Autor

• 

  Marcos Gómez Revuelta

  Autor

• 

  Paula Suárez Pinilla

  Autor

• 

  Claudia Ovejas Catalán

  Autor

• 

  Paloma Guadalupe Fuentes Pérez

  Autor

• Mario Ruiz Nuñez

  Autor

• Roberto Garrastazu Lopez

  Autor

• 

  María Juncal Ruiz

  Autor

• 

  Javier Vázquez Bourgon

  Autor

Autores ajenos al IDIVAL

• Crespo-Facorro B

Unidades

• PSIQUIATRÍA Y SALUD MENTAL

  

  Investigador Responsable

  Javier Vázquez Bourgon

Abstract

BACKGROUND: Tobacco smoking has been described as the main cause of chronic obstructive pulmonary disease (COPD) and this habit is clearly more frequent among individuals with psychosis than in the general population, with rates reaching up to 60%. However, little attention has been focused on the association of COPD and psychosis. We aimed to explore the risk of presenting early lung function alterations in a group of individuals with psychosis. METHODS: Following an observational cross-sectional design we studied a cohort of individuals with established psychosis (N=128), and compared them with a sex, age, and smoking habit matched control group (N=79). We evaluated respiratory symptoms by means of mMRC, CAT and Dyspnea-12 scales. And lung function through spirometry tests. RESULTS: Individuals with psychosis presented more respiratory symptoms than controls. Similarly, we observed significant differences in the lung function tests between these two groups, where individuals with psychosis presented worse results in most of the spirometry mean values (FEV1 or forced expiratory volume in the first one second: 3.29L vs. 3.75L, p<0.001; forced vital capacity or FVC: 4.25L vs. 4.72L, p=0.002; and FEV1/FVC ratio: 0.78 vs. 0.80, p=0.052). Patients also presented worse values of lung diffusion, with lower diffusing capacity for carbon monoxide (DLCO) than controls (6.95 vs. 8.54mmol/min/kPa, p<0.001). CONCLUSIONS: The individuals with psychosis in our study presented greater respiratory symptoms and poorer lung function measured through spirometry. These signs have been described as early signs of COPD.

Copyright © 2023 Sociedad Española de Psiquiatría y Salud Mental (SEPSM). Published by Elsevier España S.L.U. All rights reserved.

Keywords

• COPD; Lung function; Psychosis; Spirometry; Tobacco smoking habit