1. Inicio
  2. Publicaciones
  3. Clinical and genetic factors involved in Porto-sinusoidal vascular disorder after oxaliplatin exposure.

Clinical and genetic factors involved in Porto-sinusoidal vascular disorder after oxaliplatin exposure.

Fecha de publicación: Fecha Ahead of Print:

Autores de IDIVAL

Autores ajenos al IDIVAL

  • Del Pozo C
  • Serrano M
  • Giráldez A
  • Tellez L
  • Magaz M
  • Ibañez L
  • Garcia J
  • Llop E
  • Alvarez-Navascues C
  • Romero M
  • Antón A
  • Albillos A
  • Hernández-Gea V
  • Garcia-Pagán JC
  • Bañares R
  • by REHEVASC group

Unidades

Abstract

BACKGROUND AND AIMS: Oxaliplatin (OX) has been described as a potential etiologic agent for porto-sinusoidal vascular disorder (PSVD). Our aim was to describe the natural history of PSVD due to OX in colon cancer (CRC) and identify risk factors for its development. METHODS: We made a multicenter retrospective case-control (ratio 1:3) study with patients diagnosed of PSVD-OX. Baseline data, end of treatment, years of follow-up and diagnosis of PSVD were collected and compared to controls (without PSVD). Besides, 16 different SNPs were selected from bibliography and analyzed by genotyping in the case group to identify potential genetic risk factors. RESULTS: 41 cases were identified, with a median time to PSVD diagnosis after the end of OX of 34 months. Spleen diameter was the strongest predictor of PSVD during treatment (OR 43.94 (14.48-133.336); p < 0.0001). Additionally, thrombocytopenia (<150 × 10^9) at one year was a significant disease risk marker (OR 9.35; 95% CI: 3.71-23.58; p = 0.001). We could not establish any significant association between the selected SNPs and PSVD diagnosis. CONCLUSION: The increase of spleen diameter is the strongest predictor of PSVD in patients treated with OX for CRC. These patients could be candidates for a specific follow-up of portal hypertension-related complications.

Copyright © 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
1590-8658, 1878-3562

DIGESTIVE AND LIVER DISEASE  ELSEVIER SCIENCE INC

Tipo:
Article
Páginas:
1721-1729
PubMed:
38719628
Enlace a otro recurso:
www.sciencedirect.com

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • Idiopathic portal hypertension; Oxaliplatin; Portal hypertension; Porto-sinusoidal vascular disorder

Compartir