Actividad Investigadora
Evaluating the usefulness of C5 and C5AR1 as genetic biomarkers of IgA-mediated vasculitis.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IDIVAL
Autores ajenos al IDIVAL
- Mora-Gil MS
- Leonardo MT
- Peñalba AC
- Narváez J
- Sevilla-Pérez B
- Callejas-Rubio JL
- Gabrie L
- Caminal-Montero L
- Collado P
- Valls MJR
- de Argila D
- Quiroga-Colina P
- Vicente-Rabaneda EF
- Rubio E
- Luque ML
- Blanco-Madrigal JM
- Galíndez-Agirregoikoa E
Unidades
Abstract
BACKGROUND: IgA-mediated vasculitis (IgAV) is a complex inflammatory disease. Unravelling its genetic background would allow us to identify genetic biomarkers that may be used as additional tools in its daily management, helping to solve the clinical challenge that this vasculitis entails. C5 is a potent immune mediator that is proteolytically processed to generate C5a, a potent anaphylatoxin that exerts its function via C5aR1. C5 downstream variants (rs3761847 and rs10818488) have been recently related to IgAV pathogenesis. Additionally, C5a and C5aR1 dysregulation contributes to the development of inflammatory diseases, and, particularly, elevated C5a plasma levels have been observed in IgAV patients in the acute stage. Accordingly, we aimed to evaluate the influence of C5 and C5AR1 on the pathophysiology of IgAV. METHODS: Eight C5 (rs10760128, rs74971050, rs4310279, rs7868761, rs10818495, rs10156396, rs3815467, and rs16910280) and three C5AR1 (rs10853784, rs11673071, and rs11670789) tag variants were genotyped in 342 Caucasian IgAV patients and 723 ethnically matched healthy controls. RESULTS: No statistically significant differences were observed when C5 and C5AR1 frequencies were compared between IgAV patients and healthy controls. Likewise, similar C5 and C5AR1 frequencies were observed amongst IgAV patients stratified according to IgAV severity (presence/absence of nephritis). Furthermore, no C5 and C5AR1 differences were disclosed when IgAV patients were stratified according to demographic and clinical IgAV characteristics other than nephritis (age at disease onset, presence/absence of joint and gastrointestinal manifestations) and sex. CONCLUSIONS: Our results suggest that C5 and C5AR1 are not related to IgAV pathogenesis and, therefore, these genes may not be useful as IgAV genetic biomarkers.
© 2025. The Author(s).
Datos de la publicación
- ISSN/ISSNe:
- 1076-1551, 1528-3658
- Tipo:
- Article
- Páginas:
- 267-267
- PubMed:
- 40717085
MOLECULAR MEDICINE BLACKWELL SCIENCE PUBL INC CAMBRIDGE
Citas Recibidas en Web of Science: 1
Documentos
- No hay documentos
Filiaciones
Keywords
- C5; C5AR1; Biomarkers; Genetics; IgA Vasculitis
Campos de Estudio
Financiación
Proyectos asociados
Caracterización de las bases moleculares de la vasculitis mediada por IgA
Investigador Principal: Raquel López Mejías
PI18/00042 . INSTITUTO DE SALUD CARLOS III. . 2019
Caracterización de las bases moleculares de la vasculitis mediada por IgA mediante secuenciación del transcriptoma de célula única de linfocitos B circulantes
Investigador Principal: Raquel López Mejías
PI21/00042 . INSTITUTO DE SALUD CARLOS III. . 2022
Contratos Miguel Servet Tipo II
Investigador Principal: Raquel López Mejías
CPII21/00004 . INSTITUTO DE SALUD CARLOS III. . 2022
Contratos predoctorales de formación en investigación en salud (PFIS)
Investigador Principal: Raquel López Mejías
FI22/00020 . INSTITUTO DE SALUD CARLOS III. . 2023
Perfil epigenómico de la vasculitis IgA: primer estudio de accesibilidad de la cromatina en todo el genoma a nivel de célula única de linfocitos B circulantes.
Investigador Principal: Raquel López Mejías
PI24/00382 . INSTITUTO DE SALUD CARLOS III. . 2025
