Characterising negative symptoms in schizophrenia: CHANSS study protocol.

Fecha de publicación: 06/11/2025 Fecha Ahead of Print: 06/11/2025

Autores de IDIVAL

Autores ajenos al IDIVAL

Wolpe N
Aymerich C
Jin Y
Martin-Subero M
Zirilli R
Shatford S
Cox R
Cartier M
Catalan A
Mane A
Pratt J
Airey L
Stanley P
Close A
Hall A
Del Santo F
Garcia-Portilla MP
Segarra N
Zhao YJ
Fletcher PC
Husain M
Jones PB
Fernandez-Egea E

Unidades

PSIQUIATRÍA Y SALUD MENTAL

Investigador Responsable

Javier Vázquez Bourgon

Abstract

BACKGROUND: Negative symptoms in schizophrenia, particularly motivational deficits, pose significant challenges to treatment and recovery. Despite their profound impact on functional outcomes, these symptoms remain poorly understood and inadequately addressed by current interventions. AIMS: The CHANSS (Characterising Negative Symptoms in Schizophrenia) study aims to dissect the cognitive mechanisms underlying motivational impairments by focusing on three interconnected domains: executive cognition, motivational cognition and meta-cognition. METHOD: This large, international, cross-sectional study recruits a heterogeneous sample of patients across illness stages - from first-episode psychosis to treatment-resistant schizophrenia - and uses a comprehensive cognitive battery, clinical scales, self-report measures and computerised cognitive tasks. Four novel tasks assess key processes in motivated behaviour: option generation, reward-based decision-making, risk sensitivity and performance self-evaluation. By incorporating control for secondary influences like depression, psychosis, sedation and illness chronicity, the study seeks to identify distinct cognitive and behavioural subtypes within motivational dysfunction. RESULTS: CHANSS tests the hypothesis that specific patient profiles exhibit predominant impairments in one or more cognitive domains, which may differentially affect goal-directed behaviour. The study's design allows exploration of hierarchical relationships between cognitive processes, such as how neurocognitive deficits may cascade to impair motivation and self-evaluation. CONCLUSIONS: Ultimately, CHANSS aims to advance mechanistic understanding of motivational deficits in schizophrenia and pave the way for personalised, targeted interventions. Its findings may inform future clinical trials and contribute to a shift away from one-size-fits-all approaches towards more effective, stratified treatment strategies in schizophrenia.

Datos de la publicación

ISSN/ISSNe:: 2056-4724,
Tipo:: Article
Páginas:: -
DOI:: 10.1192/bjo.2025.10880
PubMed:: 41195453

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Métricas

Filiaciones

Wolpe N:: Department of Physical Therapy, The Stanley Steyer School of Health Professions, Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel

Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
Aymerich C:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK

Child and Adolescent Mental Health Services, South London and Maudsley NHS Foundation Trust, London, UK
Jin Y:: Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China
Martin-Subero M:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

Institute of Mental Health, Parc de Salut Mar, Barcelona, Spain
Fuentes-Perez P:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

Hospital del Mar Foundation Medical Research Institute (IMIM), Barcelona, Spain

Instituto de Investigación. Health Research Institute Valdecilla (IDIVAL), Santander, Spain
Ovejas-Catalan C:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

Hospital del Mar Foundation Medical Research Institute (IMIM), Barcelona, Spain

Instituto de Investigación. Health Research Institute Valdecilla (IDIVAL), Santander, Spain
Salas-Rad S:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

Hospital del Mar Foundation Medical Research Institute (IMIM), Barcelona, Spain

Instituto de Investigación. Health Research Institute Valdecilla (IDIVAL), Santander, Spain
Zirilli R:: Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK
Shatford S:: Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK
Cox R:: Clinical Research Unit, South West London & St George's Mental Health NHS Trust, London, UK
Cartier M:: Clinical Research Unit, South West London & St George's Mental Health NHS Trust, London, UK
Catalan A:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

Department of Neuroscience, University of the Basque Country UPV/EHU, Biscay, Spain

Department of Psychiatry, Basurto University Hospital, OSI Bilbao-Basurto, Bilbao, Spain

Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, King's College London, London, UK

Biobizkaia Health Research Institute, Barakaldo, Bizkaia, Spain
Mane A:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

Grup MERITT, Sant Joan de Deu Research Institute, Parc Sanitari Sant Joan de Déu, Spain
Pratt J:: Research Team, Humber NHS Foundation Trust, Hull, UK
Airey L:: Research Team, Humber NHS Foundation Trust, Hull, UK
Stanley P:: Grounded Research, Rotherham, Doncaster and South Humber NHS Foundation Trust, Doncaster, UK
Close A:: Grounded Research, Rotherham, Doncaster and South Humber NHS Foundation Trust, Doncaster, UK
Hall A:: Grounded Research, Rotherham, Doncaster and South Humber NHS Foundation Trust, Doncaster, UK
Vazquez-Bourgon J:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

Hospital del Mar Foundation Medical Research Institute (IMIM), Barcelona, Spain

Instituto de Investigación. Health Research Institute Valdecilla (IDIVAL), Santander, Spain

University Hospital Marqués de Valdecilla - University of Cantabria, Santander, Spain
Del Santo F:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

University of Oviedo, Health Research Institute Principado de Asturias (ISPA) and Health Service of the Principality of Asturias (SESPA), Oviedo, Spain
Garcia-Portilla MP:: Spanish Network for Research in Mental Health, Carlos III Institute (CIBERSAM ISCIII), Madrid, Spain

University of Oviedo, Health Research Institute Principado de Asturias (ISPA) and Health Service of the Principality of Asturias (SESPA), Oviedo, Spain
Segarra N:: Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK
Zhao YJ:: Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China
Fletcher PC:: Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK

Department of Psychiatry, https://ror.org/013meh722University of Cambridge, Cambridge, UK
Husain M:: Department of Experimental Psychology, University of Oxford, Oxford, UK

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
Jones PB:: Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK

Department of Psychiatry, https://ror.org/013meh722University of Cambridge, Cambridge, UK
Fernandez-Egea E:: Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK

Department of Psychiatry, https://ror.org/013meh722University of Cambridge, Cambridge, UK