Actividad Investigadora
Papel de la dopamina en el eje cerebro-hígado asociado a la aparición de enfermedad hepática grasa no alcohólica en pacientes con un primer episodio de psicosis. Estudio MINERVA
Datos básicos
- Código:
- PI20/01279
- Dotación:
- 111.320,00 €
- Año Inicial:
- 2021
- Año final:
- 2025
Objetivos del proyecto
Main objective: To evaluate the longitudinal effect of NAFLD and cardiovascular risk, on progression of structural changes and cognitive function, in a sample of patients diagnosed with first episode of psychosis. Specific objectives 1. To evaluate the incidence of liver disease, through imaging techniques (ultrasound scan - US -, magnetic resonance imaging-estimated proton density fat fraction - MRI-PDFF - and transient elastography with controlled attenuation parameter - CAP -) combined with steatosis and fibrosis indexes, in the second year of the illness, in drug-naïve patients with a first episode of psychosis. 2. To explore the incidence of early signs of cardiovascular pathology, through the study of endothelial dysfunction and subclinical atherosclerosis (EndoPAT2000® and carotid ultrasound study), in a sample of patients with a nonaffective psychosis. 3. To identify early biomarkers based on transcriptional changes in PBMCs predicting mid-term (2 years) liver disease NAFLD and/or endothelial alterations, and brain and cognitive changes, in a sample of patients with first episode of psychosis. 4. To analyze the relation between mid-term (2 years) brain structural and neurocognitive changes, and NAFLD and endothelial dysfunction/subclinical atherosclerosis. 5. To detect differentially expressed genes participating in the development of NAFLD in psychosis 5.1 Whole mRNA transcriptome analysis in PBMCs from a cohort of clinically characterized psychotic patients that will be clustered as NAFLD negative vs. -NAFLD positive patients. 5.2 To validate the expression of the 17 clinically associated genes deregulated in first episode psychosis using RTqPCR in the above-mentioned cohort of cases associated with the development of NAFLD 5.3 To study the underlying mechanisms that control the expression of the significant genes found in this study in a dopaminergic D1 context in vitro/ex-vivo
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