Actividad Investigadora
Anthropometry in antipsychotic-naïve first-episode psychosis patients: An exploratory approach to the role of environmental early life events in two independent samples
Fecha de publicación:
Fecha Ahead of Print:
Autores de IDIVAL
Autores ajenos al IDIVAL
- Garcia-Rizo C
- Crespo-Facorro B
- Oliveira C
- Kirkpatrick B
- Son JM
- de la Hoz LC
- Garriga M
- Garrido-Torres N
- Bernardo M
- Fernandez-Egea E
Unidades
Abstract
Background: Patients with schizophrenia exhibit a reduced life expectancy mainly due to medical-related pathologies which might have been initiated due to stressful events during fetal development. Indeed, intra-uterus growth patterns predict anthropometric measures in adulthood, describing risk factors for schizophrenia and metabolic disorders. We aim to evaluate anthropometric values in two cohorts of antipsychotic-na & iuml;ve firstepisode episode psychosis (FEP) and correlated them with surrogate markers of the fetal environment such as birth weight (BW) and season of birth. Methods: BW, season of birth, and anthropometric values from 2 cohorts of FEP patients (Barcelona and Santander) were evaluated. In cohort B, 91 patients, and 110 controls while in cohort S, 644 and 235 were included respectively. Results: Patients were shorter, slimmer, and with lower BMI compared with controls. In both cohorts, patients, and female patients born in winter displayed the shortest height. Regarding BW, height was significantly associated with the interaction of diagnosis and BW in the whole sample and the male subsample. Conclusions: Our results confirm reduced anthropometric features in FEP at onset while suggesting the influence of winter birth and BW, highlighting the role of early life events in the later outcome of FEP with sex differences.
Datos de la publicación
- ISSN/ISSNe:
- 0920-9964, 1573-2509
- Tipo:
- Article
- Páginas:
- 216-226
- PubMed:
- 38428119
SCHIZOPHRENIA RESEARCH ELSEVIER SCIENCE BV
Citas Recibidas en Web of Science: 2
Documentos
- No hay documentos
Filiaciones
Keywords
- First episode psychosis; Schizophrenia; Anthropometry; Epiphenomena; Birth weight; Winter birth
Campos de Estudio
Financiación
Proyectos asociados
Papel de la dopamina en el eje cerebro-hígado asociado a la aparición de enfermedad hepática grasa no alcohólica en pacientes con un primer episodio de psicosis. Estudio MINERVA
Investigador Principal: María Teresa Arias Loste
PI20/01279 . INSTITUTO DE SALUD CARLOS III. . 2021
Ayudas Intensificación VAZQUEZ BOURGON JAVIER
Investigador Principal: Javier Vázquez Bourgon
INT/A20/04 . 2021
Ayudas Intensificación VÁZQUEZ BOURGON JAVIER
Investigador Principal: Javier Vázquez Bourgon
INT/A21/10 . 2021
Contrato para la intensificación de la actividad investigadora en el SNS
Investigador Principal: Javier Vázquez Bourgon
INT22/00029 . 2023
