Actividad Investigadora
Papel de CREB y STAT3 activados como conductores en cánceres agresivos de la piel: aplicaciones para el diagnóstico y tratamiento del linfoma cutáneo de células T y carcinoma de células de Merkel
Datos básicos
- Código del Financiador:
- PI19/00204
- Año Inicial:
- 2020
- Año final:
- 2023
Objetivos del proyecto
Objective-1. Mechanistic and Functional analysis in CTCL cell models. This objective will be mainly performed at the laboratories located in UC and IDIVAL. It will last 2,5 years that will include generation and validation of mechanistic, transcriptome and protein interactome data in CTCL. Objective-2 Biological implications: we will use CTCL cells ex vivo as well as CTCL xenografts in chicken embryos. This will take the last 2 years and will monitor the role of specific PLCG1/PKCĮ-downstream effectors in cellular proliferation and viability and also in tumorigenesis and dissemination in vivo. Objective-3. Clinical validation. It will last the entire project to ensure a proper clinical sample collection and characterization in a timely coordinated manner to enable specific molecular analyses and validations. Our team has wide and documented expertise in this translational activity since it requires a tight coordination between clinicians and basic researchers.
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