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Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Gualillo, O
  • Ferraz-Amaro, I

Unidades

Abstract

Introduction: Early diagnosis of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary vasculopathy is relevant in the development of interstitial lung disease. Accordingly, we aimed to explore the role of vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and asymmetric dimethylarginine (ADMA), key molecules in the vasculopathy, as potential biomarkers of pulmonary fibrosis in RA-ILD+. Methods: We included 21 RA-ILD+ patients and two comparative groups: 25 RA-ILD- patients and 21 idiopathic pulmonary fibrosis (IPF) patients. Serum levels of the molecules were determined by ELISA, and mRNA expression was quantified by qPCR. Results: VCAM-1, MCP-1 and ADMA serum levels were increased in RA-ILD+ patients in relation to RA-ILD- and IPF patients. Additionally, RA-ILD+ patients exhibited increased CCL2 (gene encoding MCP-1) and decreased PRMT1 (gene related to ADMA synthesis) mRNA expression in relation to RA-ILD- patients. A lower expression of VCAM1, CCL2, and PRMT1 was observed in RA-ILD+ patients when compared with those with IPF. Furthermore, MCP-1 serum levels and PRMT1 mRNA expression were positively correlated with RA duration, and ADMA serum levels were positively associated with C-reactive protein in RA-ILD+ patients. Conclusion: Our study suggests that VCAM-1, MCP-1 and ADMA could be considered as useful biomarkers to identify ILD in RA patients, as well as to discriminate RA-ILD+ from IPF, contributing to the early diagnosis of RA-ILD+.

Copyright © 2022 Pulito-Cueto, Remuzgo-Martínez, Genre, Atienza-Mateo, Mora-Cuesta, Iturbe-Fernández, Lera-Gómez, Sebastián Mora-Gil, Prieto-Peña, Portilla, Blanco, Corrales, Ocejo-Vinyals, Gualillo, Ferraz-Amaro, Cifrián, López-Mejías and González-Gay.

Datos de la publicación

ISSN/ISSNe:
2296-889X, 2296-889X

Frontiers in Molecular Biosciences  FRONTIERS MEDIA SA

Tipo:
Article
Páginas:
1056121-1056121
PubMed:
36601584

Citas Recibidas en Web of Science: 23

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Keywords

  • VCAM-1; MCP-1; ADMA; interstitial lung disease; rheumatoid arthritis; biomarkers; pulmonary fibrosis

Campos de Estudio

Proyectos asociados

Caracterización de las bases moleculares de la vasculitis mediada por IgA

Investigador Principal: Raquel López Mejías

PI18/00042 . INSTITUTO DE SALUD CARLOS III. . 2019

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