Actividad Investigadora
Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis
Fecha de publicación:
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Autores de IDIVAL
Autores ajenos al IDIVAL
- Remuzgo-Martinez, S
- Lera-Gomez, L
- Mora-Gil, MS
- Gualillo, O
- Ferraz-Amaro, I
- Gonzalez-Gay, MA
Unidades
Abstract
Introduction: Early diagnosis of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary vasculopathy is relevant in the development of interstitial lung disease. Accordingly, we aimed to explore the role of vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and asymmetric dimethylarginine (ADMA), key molecules in the vasculopathy, as potential biomarkers of pulmonary fibrosis in RA-ILD+. Methods: We included 21 RA-ILD+ patients and two comparative groups: 25 RA-ILD- patients and 21 idiopathic pulmonary fibrosis (IPF) patients. Serum levels of the molecules were determined by ELISA, and mRNA expression was quantified by qPCR. Results: VCAM-1, MCP-1 and ADMA serum levels were increased in RA-ILD+ patients in relation to RA-ILD- and IPF patients. Additionally, RA-ILD+ patients exhibited increased CCL2 (gene encoding MCP-1) and decreased PRMT1 (gene related to ADMA synthesis) mRNA expression in relation to RA-ILD- patients. A lower expression of VCAM1, CCL2, and PRMT1 was observed in RA-ILD+ patients when compared with those with IPF. Furthermore, MCP-1 serum levels and PRMT1 mRNA expression were positively correlated with RA duration, and ADMA serum levels were positively associated with C-reactive protein in RA-ILD+ patients. Conclusion: Our study suggests that VCAM-1, MCP-1 and ADMA could be considered as useful biomarkers to identify ILD in RA patients, as well as to discriminate RA-ILD+ from IPF, contributing to the early diagnosis of RA-ILD+.
Copyright © 2022 Pulito-Cueto, Remuzgo-Martínez, Genre, Atienza-Mateo, Mora-Cuesta, Iturbe-Fernández, Lera-Gómez, Sebastián Mora-Gil, Prieto-Peña, Portilla, Blanco, Corrales, Ocejo-Vinyals, Gualillo, Ferraz-Amaro, Cifrián, López-Mejías and González-Gay.
Datos de la publicación
- ISSN/ISSNe:
- 2296-889X, 2296-889X
- Tipo:
- Article
- Páginas:
- 1056121-1056121
Frontiers In Molecular Biosciences Frontiers Media S.A.
Citas Recibidas en Web of Science: 14
Documentos
- No hay documentos
Filiaciones
Keywords
- VCAM-1; MCP-1; ADMA; interstitial lung disease; rheumatoid arthritis; biomarkers; pulmonary fibrosis
