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  3. Torque Teno Virus Load Predicts Opportunistic Infections after Kidney Transplantation but Is Not Associated with Maintenance Immunosuppression Exposure

Torque Teno Virus Load Predicts Opportunistic Infections after Kidney Transplantation but Is Not Associated with Maintenance Immunosuppression Exposure

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Canamero, L
  • Escagedo, C
  • Rodriguez-Vidriales, M

Unidades

Abstract

Measuring the non-pathogenic Torque Teno Virus (TTV) load allows assessing the net immunosuppressive state after kidney transplantation (KTx). Currently, it is not known how exposure to maintenance immunosuppression affects TTV load. We hypothesized that TTV load is associated with the exposure to mycophenolic acid (MPA) and tacrolimus. We performed a prospective study including 54 consecutive KTx. Blood TTV load was measured by an in-house PCR at months 1 and 3. Together with doses and trough blood levels of tacrolimus and MPA, we calculated the coefficient of variability (CV), time in therapeutic range (TTR) and concentration/dose ratio (C/D) of tacrolimus, and the MPA-area under the curve (AUC-MPA) at the third month. TTV load at the first and third month discriminated those patients at risk of developing opportunistic infections between months 1 and 3 (AUC-ROC 0.723, 95%CI 0.559-0.905, p = 0.023) and between months 3 and 6 (AUC-ROC 0.778, 95%CI 0.599-0.957, p = 0.028), respectively, but not those at risk of acute rejection. TTV load did not relate to mean tacrolimus blood level, CV, TTR, C/D and AUC-MPA. To conclude, although TTV is a useful marker of net immunosuppressive status after KTx, it is not related to exposure to maintenance immunosuppression.

Datos de la publicación

ISSN/ISSNe:
2227-9059, 2227-9059

Biomedicines  MDPI AG

Tipo:
Article
Páginas:
-
PubMed:
37239081

Citas Recibidas en Web of Science: 12

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Keywords

  • Torque Teno virus; acute rejection; immunosuppression; infection; kidney transplantation; monitoring

Proyectos asociados

Cambios postrasplante en las células T foliculares helper analizados mediante una valoración integral de los factores de riesgo de desarrollar anticuerpos específicos de donante “de novo”

Investigador Principal: Emilio Rodrigo Calabia

PI20/01710 . INSTITUTO DE SALUD CARLOS III. . 2021

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