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Endothelial Progenitor Cells: Relevant Players in the Vasculopathy and Lung Fibrosis Associated with the Presence of Interstitial Lung Disease in Systemic Sclerosis Patients

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Autores de IDIVAL

Autores ajenos al IDIVAL

  • Remuzgo-Martínez S
  • Lera-Gómez L
  • Pérez-Fernández R
  • Gualillo O
  • González-Gay MA

Unidades

Abstract

Endothelial progenitor cells (EPC), which are key effectors in the physiologic vascular network, have been described as relevant players in autoimmune diseases. We previously showed that EPC frequency may help to identify the presence of interstitial lung disease (ILD) in rheumatoid arthritis patients. Given that ILD constitutes the main cause of mortality in systemic sclerosis (SSc) patients, we aimed to determine the EPC contribution to the pathogenic processes of vasculopathy and lung fibrosis in SSc-ILD+. EPC quantification was performed by flow cytometry on blood from 83 individuals: 21 SSc-ILD+ patients and subjects from comparative groups (20 SSc-ILD- and 21 idiopathic pulmonary fibrosis (IPF) patients and 21 healthy controls (HC)). EPC were considered as CD34(+), CD45(low), CD309(+), and CD133(+). A significant increase in EPC frequency was found in SSc-ILD+ patients when compared to HC (p < 0.001). SSc-ILD+ patients exhibited a higher EPC frequency than SSc-ILD- patients (p = 0.012), whereas it was markedly reduced compared to IPF patients (p < 0.001). EPC frequency was higher in males (p = 0.04) and negatively correlated to SSc duration (p = 0.04) in SSc-ILD+ patients. Our results indicate a role of EPC in the processes of vasculopathy and lung fibrosis in SSc-ILD+. EPC frequency may be considered as a biomarker of ILD in SSc patients.

Datos de la publicación

ISSN/ISSNe:
2227-9059, 2227-9059

Biomedicines  MDPI AG

Tipo:
Article
Páginas:
-

Citas Recibidas en Web of Science: 12

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Keywords

  • biomarker; endothelial progenitor cells; interstitial lung disease; systemic sclerosis

Financiación

ERDFEuropean Commission (PI17/00409)
ERDFEuropean Commission (RD16/0012/0014)
European Regional Development Fund
FOUNDATION FOR RESEARCH IN RHEUMATOLOGY (FOREUM18/34)
FUNDACION INSTITUTO DE INVESTIGACION MARQUES DE VALDECILLA (INNVAL20/06)
IDIVAL (PREVAL 18/01)
INSTITUTO DE SALUD CARLOS III. (RD16/0012/0009)
Miguel Servet type I fellowship (`Investing in your future' [CP16/00033)
Miguel Servet type I fellowship (ISCIII] - European Social Fund)
Research Executive Agency (734899-Olive-Net)
Servizo Galego de Saude

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